Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1997-6-26
|
pubmed:abstractText |
The ontogeny of circulating concentrations of insulin-like growth factor (IGF-)-I, IGF-II, and IGF-binding proteins (IGF-BPs) was examined in the chick embryo. Distinct ontogenic changes in the circulating concentrations of IGF-I and IGF-II were observed. The present study confirms the overall profile for circulating concentrations of IGF-I. During middevelopment, plasma concentrations of IGF-I increased to a maximum which was attained on Day 14.5 of incubation. Thereafter, plasma concentrations of IGF-I declined with decreases (P < 0.05) between Days 14.5 and 15.5 and between Days 16.5 and 17.5 of incubation. In contrast to the monophasic profile for IGF-I, plasma concentrations of IGF-II were maximal on Day 10.5 of incubation and declined to a nadir on Day 17.5 of incubation. In late developmental stages (17.5 or 18.5 days of incubation), three IGF-BPs, having molecular weights of 22, 28, and 36 kDa, were detected in the plasma of chick embryos. No significant ontogenic changes in the circulating levels of the 28- and 36-kDa IGF-BPs were observed. However, it should be noted that prior to Day 17.5 of incubation, the 22-kDa IGF-BP was nondetectable in the circulation. The role of these changes in the functioning of IGF in embryonic development is discussed.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Insulin-Like Growth Factor Binding...,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin-Like Growth Factor I,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin-Like Growth Factor II,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Somatotropin
|
pubmed:status |
MEDLINE
|
pubmed:month |
May
|
pubmed:issn |
0016-6480
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
106
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
265-70
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:9169122-Animals,
pubmed-meshheading:9169122-Blotting, Western,
pubmed-meshheading:9169122-Body Weight,
pubmed-meshheading:9169122-Chick Embryo,
pubmed-meshheading:9169122-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:9169122-Embryonic and Fetal Development,
pubmed-meshheading:9169122-Insulin-Like Growth Factor Binding Proteins,
pubmed-meshheading:9169122-Insulin-Like Growth Factor I,
pubmed-meshheading:9169122-Insulin-Like Growth Factor II,
pubmed-meshheading:9169122-Molecular Weight,
pubmed-meshheading:9169122-Radioimmunoassay,
pubmed-meshheading:9169122-Receptors, Somatotropin
|
pubmed:year |
1997
|
pubmed:articleTitle |
Ontogenic changes in the circulating concentrations of insulin-like growth factor (IGF)-I, IGF-II, and IGF-binding proteins in the chicken embryo.
|
pubmed:affiliation |
Department of Animal Sciences, Rutgers, State University of New Jersey, New Brunswick 08903, USA.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|