Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1997-6-23
pubmed:abstractText
The mechanisms of pressure and flow generation in the initial lymphatic network remain undefined in many details. Active pump mechanisms by lymph smooth muscle contraction have been demonstrated in collecting lymph ducts while passive mechanisms by periodic lymph compression in noncontractile initial lymphatics have received relative little attention. The aim of this study was to examine lymph flow before and during periodic passive tissue deformation under different lymph outflow pressures. Lymph flow rate and lymph outflow pressure were measured in rabbit popliteal prenodal lymphatics during whole leg rotations. The hind legs were rotated in a sagittal plane at selected frequencies. During constant leg rotation, lymph flow rates reached steady levels which depend on lymph outflow pressure. When lymph outflow was occluded, intralymphatic pressures increased progressively to levels which depend on leg rotation frequency. Both lymph flow rate and pressure showed higher values with foot edema than in the absence of foot edema. These results suggest that periodic tissue deformation, lymph outflow pressure, and interstitial free fluid volume are important determinants of the lymph flow rate.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0024-7766
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
13-23
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Fluid pressures in the rabbit popliteal afferent lymphatics during passive tissue motion.
pubmed:affiliation
Department of Bioengineering, University of California, San Diego, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't