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| pubmed-article:9030620 | lifeskim:mentions | umls-concept:C0027836 | lld:lifeskim |
| pubmed-article:9030620 | lifeskim:mentions | umls-concept:C0205147 | lld:lifeskim |
| pubmed-article:9030620 | lifeskim:mentions | umls-concept:C1882598 | lld:lifeskim |
| pubmed-article:9030620 | lifeskim:mentions | umls-concept:C0080093 | lld:lifeskim |
| pubmed-article:9030620 | lifeskim:mentions | umls-concept:C0678723 | lld:lifeskim |
| pubmed-article:9030620 | lifeskim:mentions | umls-concept:C0475264 | lld:lifeskim |
| pubmed-article:9030620 | lifeskim:mentions | umls-concept:C0949370 | lld:lifeskim |
| pubmed-article:9030620 | lifeskim:mentions | umls-concept:C0458003 | lld:lifeskim |
| pubmed-article:9030620 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:9030620 | pubmed:dateCreated | 1997-3-26 | lld:pubmed |
| pubmed-article:9030620 | pubmed:abstractText | D-Serine is localized in mammalian brain to a discrete population of glial cells near NMDA receptors, suggesting that D-serine is an endogenous agonist of the receptor-associated glycine site. To explore this possibility, we have compared the immunohistochemical localizations of D-serine, glycine, and NMDA receptors in rat brain. In the telencephalon, D-serine is concentrated in protoplasmic astrocytes, which are abundant in neuropil in close vicinity to NMDA receptor 2A/B subunits. Ultrastructural examination of the CA1 region of hippocampus reveals D-serine in the cytosolic matrix of astrocytes that ensheath neurons and blood vessels, whereas NR2A/B is concentrated in dendritic spines. By contrast, glycine immunoreactivity in telencephalon is the lowest in brain. During postnatal week 2, D-serine levels in cerebellum are comparable to those in adult cerebral cortex but fall to undetectable levels by day 26. During week 2, we observe parallel ontogeny of D-serine in Bergmann glia and NR2A/B in Purkinje cells, suggesting a role for astrocytic D-serine in NMDA receptor-mediated synaptogenesis. D-Serine in the radial processes of Bergmann glia is also well positioned to regulate NMDA receptor-dependent granule cell migration. In the inner granule layer, D-serine is found transiently in protoplasmic astrocytes surrounding glomeruli, where it could regulate development of the mossy fiber/granule cell synapse. D-Serine seems to be the endogenous ligand of glycine sites in the telencephalon and developing cerebellum, whereas glycine predominates in the adult cerebellum, olfactory bulb, and hindbrain. | lld:pubmed |
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| pubmed-article:9030620 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:9030620 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9030620 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9030620 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:9030620 | pubmed:issn | 0270-6474 | lld:pubmed |
| pubmed-article:9030620 | pubmed:author | pubmed-author:SnyderS HSH | lld:pubmed |
| pubmed-article:9030620 | pubmed:author | pubmed-author:MolliverM EME | lld:pubmed |
| pubmed-article:9030620 | pubmed:author | pubmed-author:SchellM JMJ | lld:pubmed |
| pubmed-article:9030620 | pubmed:author | pubmed-author:BradyR OROJr | lld:pubmed |
| pubmed-article:9030620 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9030620 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:9030620 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:9030620 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9030620 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9030620 | pubmed:pagination | 1604-15 | lld:pubmed |
| pubmed-article:9030620 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:9030620 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9030620 | pubmed:articleTitle | D-serine as a neuromodulator: regional and developmental localizations in rat brain glia resemble NMDA receptors. | lld:pubmed |
| pubmed-article:9030620 | pubmed:affiliation | Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. | lld:pubmed |
| pubmed-article:9030620 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9030620 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9030620 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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