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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1997-3-26
|
| pubmed:abstractText |
D-Serine is localized in mammalian brain to a discrete population of glial cells near NMDA receptors, suggesting that D-serine is an endogenous agonist of the receptor-associated glycine site. To explore this possibility, we have compared the immunohistochemical localizations of D-serine, glycine, and NMDA receptors in rat brain. In the telencephalon, D-serine is concentrated in protoplasmic astrocytes, which are abundant in neuropil in close vicinity to NMDA receptor 2A/B subunits. Ultrastructural examination of the CA1 region of hippocampus reveals D-serine in the cytosolic matrix of astrocytes that ensheath neurons and blood vessels, whereas NR2A/B is concentrated in dendritic spines. By contrast, glycine immunoreactivity in telencephalon is the lowest in brain. During postnatal week 2, D-serine levels in cerebellum are comparable to those in adult cerebral cortex but fall to undetectable levels by day 26. During week 2, we observe parallel ontogeny of D-serine in Bergmann glia and NR2A/B in Purkinje cells, suggesting a role for astrocytic D-serine in NMDA receptor-mediated synaptogenesis. D-Serine in the radial processes of Bergmann glia is also well positioned to regulate NMDA receptor-dependent granule cell migration. In the inner granule layer, D-serine is found transiently in protoplasmic astrocytes surrounding glomeruli, where it could regulate development of the mossy fiber/granule cell synapse. D-Serine seems to be the endogenous ligand of glycine sites in the telencephalon and developing cerebellum, whereas glycine predominates in the adult cerebellum, olfactory bulb, and hindbrain.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Glycine,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Neurotransmitter Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Glycine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, N-Methyl-D-Aspartate,
http://linkedlifedata.com/resource/pubmed/chemical/Serine
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0270-6474
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
17
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1604-15
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:9030620-Animals,
pubmed-meshheading:9030620-Brain Chemistry,
pubmed-meshheading:9030620-Cerebellum,
pubmed-meshheading:9030620-Glycine,
pubmed-meshheading:9030620-Hippocampus,
pubmed-meshheading:9030620-Ligands,
pubmed-meshheading:9030620-Models, Neurological,
pubmed-meshheading:9030620-Neuroglia,
pubmed-meshheading:9030620-Neurotransmitter Agents,
pubmed-meshheading:9030620-Olfactory Bulb,
pubmed-meshheading:9030620-Organ Specificity,
pubmed-meshheading:9030620-Rabbits,
pubmed-meshheading:9030620-Rats,
pubmed-meshheading:9030620-Rats, Sprague-Dawley,
pubmed-meshheading:9030620-Receptors, Glycine,
pubmed-meshheading:9030620-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:9030620-Rhombencephalon,
pubmed-meshheading:9030620-Serine,
pubmed-meshheading:9030620-Stereoisomerism,
pubmed-meshheading:9030620-Telencephalon
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
D-serine as a neuromodulator: regional and developmental localizations in rat brain glia resemble NMDA receptors.
|
| pubmed:affiliation |
Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|