Source:http://linkedlifedata.com/resource/umls/id/C0080093
MSH: A class of ionotropic glutamate receptors characterized by affinity for N-methyl-D-aspartate. NMDA receptors have an allosteric binding site for glycine which must be occupied for the channel to open efficiently and a site within the channel itself to which magnesium ions bind in a voltage-dependent manner. The positive voltage dependence of channel conductance and the high permeability of the conducting channel to calcium ions (as well as to monovalent cations) are important in excitotoxicity and neuronal plasticity.,CSP: subtype of glutamate receptor to which the synthetic aminoacid NMDA is an agonist; effectors are ligand- and voltage-gated calcium channel domains or subunits; important in excitotoxicity and neural plasticity.