Linked Life Data

8916146

Source:http://linkedlifedata.com/resource/pubmed/id/8916146

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1997-2-18
pubmed:abstractText
In situ expression of apoptosis and its related antigens has rarely been evaluated in human liver tumors. Therefore, investigation using in situ nick end-labeling and immunohistochemical methods of the in situ expression of apoptosis, proliferating cells, and apoptosis-related antigens in 7 normal livers, 20 cholangiocarcinomas (CC) and 17 hepatocellular carcinomas (HCC) was done. Apoptotic cells as determined by the nick end-labeling method and proliferating cell nuclear antigen-positive cells were present in all specimens, and the percentage of them was significantly higher in CC than in HCC. Bcl-2 protein was present only in one CC and one HCC, but was occasionally noted in bile ducts in non-cancerous livers. C-myc and Fas antigens were not found in any of the cases. Lewisy antigen was expressed in 8 CC, but was absent in the other cases although bile ducts in non-cancerous livers frequently expressed Lewisy. p53 protein was present in 8 CC, but was absent in the other cases. Serial section observations showed that apoptotic cancer cells were consistently negative for proliferating cell nuclear antigen; bcl-2-positive cells did not show apoptosis; p53-positive cancer cells showed apoptosis. Some Lewisy-positive cancer cells showed apoptosis, while others did not. These data suggest that apoptosis and cell proliferation are involved in CC and HCC, and their degree is more severe in CC than in HCC. p53 protein (stimulative) may regulate apoptosis in some cases, whereas c-myc, Fas and Lewisy are not related to apoptosis in CC and HCC in vivo. Many other factors may regulate apoptosis in CC and HCC in vivo.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1320-5463
pubmed:author
pubmed:issnType
Print
pubmed:volume
46
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
764-70
pubmed:dateRevised
2005-11-17
pubmed:meshHeading
pubmed-meshheading:8916146-Antigens, CD95, pubmed-meshheading:8916146-Apoptosis, pubmed-meshheading:8916146-Bile Duct Neoplasms, pubmed-meshheading:8916146-Bile Ducts, Intrahepatic, pubmed-meshheading:8916146-Carcinoma, Hepatocellular, pubmed-meshheading:8916146-Cholangiocarcinoma, pubmed-meshheading:8916146-DNA Nucleotidylexotransferase, pubmed-meshheading:8916146-Humans, pubmed-meshheading:8916146-Immunohistochemistry, pubmed-meshheading:8916146-In Situ Hybridization, pubmed-meshheading:8916146-Lewis Blood-Group System, pubmed-meshheading:8916146-Liver, pubmed-meshheading:8916146-Liver Neoplasms, pubmed-meshheading:8916146-Proliferating Cell Nuclear Antigen, pubmed-meshheading:8916146-Proto-Oncogene Proteins c-bcl-2, pubmed-meshheading:8916146-Proto-Oncogene Proteins c-myc, pubmed-meshheading:8916146-Tumor Suppressor Protein p53
pubmed:year
1996
pubmed:articleTitle
Expression of apoptosis, proliferating cell nuclear antigen, and apoptosis-related antigens (bcl-2, c-myc, Fas, Lewis(y) and p53) in human cholangiocarcinomas and hepatocellular carcinomas.
pubmed:affiliation
Second Department of Pathology, Kanazawa University School of Medicine, Japan.
pubmed:publicationType
Journal Article