| pubmed-article:8617306 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8617306 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:8617306 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:8617306 | lifeskim:mentions | umls-concept:C0123759 | lld:lifeskim |
| pubmed-article:8617306 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:8617306 | lifeskim:mentions | umls-concept:C0167627 | lld:lifeskim |
| pubmed-article:8617306 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:8617306 | lifeskim:mentions | umls-concept:C1539081 | lld:lifeskim |
| pubmed-article:8617306 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:8617306 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:8617306 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:8617306 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:8617306 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:8617306 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8617306 | pubmed:dateCreated | 1996-6-13 | lld:pubmed |
| pubmed-article:8617306 | pubmed:abstractText | We have previously shown that T cell receptor-activated mouse T helper (Th)1 clones induce the production of interleukin (IL)-12 by splenic antigen-presenting cells (APC). Here, we show that the expression of CD40L by activated T cells is critical for T cell-dependent IL-12 production by mouse macrophages. IL-12 was produced in cultures containing alloreactive Th1 clones stimulated with allogeneic peritoneal macrophages, or in cultures of splenocytes stimulated with anti-CD3. Anti-CD40L monoclonal antibodies (mAb) inhibited the production of IL-12, but not IL-2, in these cultures by approximately 90% and had dramatic inhibitory effects on antigen-dependent proliferation of Th1 clones. In addition, both activated T cells and a Th1 clone derived from CD40L knockout mice failed to induce IL-12 production from splenic APC or peritoneal macrophages. Finally, macrophages cultured in the absence of T cells produced IL-12 upon stimulation with soluble recombinant CD40L in combination with either supernatants from activated Th1 clones or with interferon-gamma and granulocyte/macrophage colony-stimulating factor. Thus, both CD40L-dependent and cytokine-mediated signals from activated T cells are required to induce the production of IL-12 by macrophages. A blockade at the level of IL-12 production may explain, at least in part, the dramatic ability of anti-CD40L mAb to inhibit disease in animal models that are dependent upon the generation of a cell-mediated immune response. Moreover, a defect in T cell-dependent induction of IL-12 may contribute to the immune status of humans that lack functional CD40L. | lld:pubmed |
| pubmed-article:8617306 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8617306 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617306 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8617306 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617306 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8617306 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617306 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8617306 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:8617306 | pubmed:issn | 0014-2980 | lld:pubmed |
| pubmed-article:8617306 | pubmed:author | pubmed-author:AldersonM RMR | lld:pubmed |
| pubmed-article:8617306 | pubmed:author | pubmed-author:GrabsteinK... | lld:pubmed |
| pubmed-article:8617306 | pubmed:author | pubmed-author:ChinW AWA | lld:pubmed |
| pubmed-article:8617306 | pubmed:author | pubmed-author:FanslowW CWC | lld:pubmed |
| pubmed-article:8617306 | pubmed:author | pubmed-author:CliffordK NKN | lld:pubmed |
| pubmed-article:8617306 | pubmed:author | pubmed-author:KennedyM KMK | lld:pubmed |
| pubmed-article:8617306 | pubmed:author | pubmed-author:PichaK SKS | lld:pubmed |
| pubmed-article:8617306 | pubmed:author | pubmed-author:MohlerK MKM | lld:pubmed |
| pubmed-article:8617306 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8617306 | pubmed:volume | 26 | lld:pubmed |
| pubmed-article:8617306 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8617306 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8617306 | pubmed:pagination | 370-8 | lld:pubmed |
| pubmed-article:8617306 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
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| pubmed-article:8617306 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8617306 | pubmed:articleTitle | CD40/CD40 ligand interactions are required for T cell-dependent production of interleukin-12 by mouse macrophages. | lld:pubmed |
| pubmed-article:8617306 | pubmed:affiliation | Immunex Corporation, Seattle, USA. | lld:pubmed |
| pubmed-article:8617306 | pubmed:publicationType | Journal Article | lld:pubmed |
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