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rdf:type |
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lifeskim:mentions |
umls-concept:C0013138,
umls-concept:C0026255,
umls-concept:C0033684,
umls-concept:C0036679,
umls-concept:C0237868,
umls-concept:C0542346,
umls-concept:C1514468,
umls-concept:C1519334,
umls-concept:C1546857,
umls-concept:C1621812,
umls-concept:C1622911,
umls-concept:C1705165,
umls-concept:C2700061
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pubmed:issue |
1
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pubmed:dateCreated |
1996-2-22
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pubmed:databankReference |
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pubmed:abstractText |
Mutations in the Drosophila genes pimples and three rows result in a defect of sister chromatid separation during mitosis. As a consequence, cytokinesis is also defective. However, cell cycle progression including the mitotic degradation of cyclins A and B is not blocked by the failure of sister chromatid separation, and as a result, metaphase chromosomes with twice the normal number of chromosome arms still connected in the centromeric region are observed in the following mitosis, pimples encodes a novel protein that is rapidly degraded in mitosis. Our observations suggest that Pimples and Three rows act during mitosis to release the cohesion between sister centromeres.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0092-8674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
12
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pubmed:volume |
84
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
25-35
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8548823-Amino Acid Sequence,
pubmed-meshheading:8548823-Anaphase,
pubmed-meshheading:8548823-Animals,
pubmed-meshheading:8548823-Antigens, Protozoan,
pubmed-meshheading:8548823-Base Sequence,
pubmed-meshheading:8548823-Blotting, Northern,
pubmed-meshheading:8548823-Cell Cycle Proteins,
pubmed-meshheading:8548823-Cell Division,
pubmed-meshheading:8548823-Centromere,
pubmed-meshheading:8548823-Chromatids,
pubmed-meshheading:8548823-Chromosomes,
pubmed-meshheading:8548823-Cloning, Molecular,
pubmed-meshheading:8548823-Cyclins,
pubmed-meshheading:8548823-Drosophila,
pubmed-meshheading:8548823-Gene Expression Regulation, Developmental,
pubmed-meshheading:8548823-Genes, Insect,
pubmed-meshheading:8548823-In Situ Hybridization, Fluorescence,
pubmed-meshheading:8548823-Larva,
pubmed-meshheading:8548823-Metaphase,
pubmed-meshheading:8548823-Mitosis,
pubmed-meshheading:8548823-Molecular Sequence Data,
pubmed-meshheading:8548823-Mutation,
pubmed-meshheading:8548823-Phenotype,
pubmed-meshheading:8548823-Protozoan Proteins
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pubmed:year |
1996
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pubmed:articleTitle |
Separation of sister chromatids in mitosis requires the Drosophila pimples product, a protein degraded after the metaphase/anaphase transition.
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pubmed:affiliation |
Friedrich-Miescher-Laboratorium der Max-Planck-Gesellschaft, Tübingen, Federal Republic of Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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