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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1-2
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pubmed:dateCreated |
1993-6-28
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pubmed:abstractText |
To investigate whether the feline CD 4 (fCD4) molecules are involved in infections of highly lymphotropic feline immunodeficiency virus (FIV) isolates, we expressed fCD4 stably on Crandell feline kidney cells and Felis catus whole foetus 4 cells by transfection of a cDNA encoding the fCD4 glycoprotein, and then infected them with TM 1 and TM 2 strains of FIV, which are unable to infect these cells productively. In spite of fCD 4 being expressed on these cells, no virus production was observed. This result indicates that fCD 4 expression alone cannot induce a productive infection of the FIV TM 1 and TM 2 strains.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0304-8608
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
130
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pubmed:geneSymbol |
gag
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
171-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8389115-Animals,
pubmed-meshheading:8389115-Antigens, CD4,
pubmed-meshheading:8389115-Base Sequence,
pubmed-meshheading:8389115-Cats,
pubmed-meshheading:8389115-Cell Line,
pubmed-meshheading:8389115-DNA, Viral,
pubmed-meshheading:8389115-Fetus,
pubmed-meshheading:8389115-Flow Cytometry,
pubmed-meshheading:8389115-Fluorescent Antibody Technique,
pubmed-meshheading:8389115-Genes, gag,
pubmed-meshheading:8389115-Immunodeficiency Virus, Feline,
pubmed-meshheading:8389115-Kidney,
pubmed-meshheading:8389115-Molecular Sequence Data,
pubmed-meshheading:8389115-Oligodeoxyribonucleotides,
pubmed-meshheading:8389115-Plasmids,
pubmed-meshheading:8389115-Polymerase Chain Reaction,
pubmed-meshheading:8389115-Recombinant Proteins,
pubmed-meshheading:8389115-Transfection
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pubmed:year |
1993
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pubmed:articleTitle |
Feline CD4 molecules expressed on feline non-lymphoid cell lines are not enough for productive infection of highly lymphotropic feline immunodeficiency virus isolates.
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pubmed:affiliation |
Department of Veterinary Microbiology, Faculty of Agriculture, University of Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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