| pubmed-article:8354909 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8354909 | lifeskim:mentions | umls-concept:C0085495 | lld:lifeskim |
| pubmed-article:8354909 | lifeskim:mentions | umls-concept:C0014118 | lld:lifeskim |
| pubmed-article:8354909 | lifeskim:mentions | umls-concept:C1314792 | lld:lifeskim |
| pubmed-article:8354909 | lifeskim:mentions | umls-concept:C0370215 | lld:lifeskim |
| pubmed-article:8354909 | lifeskim:mentions | umls-concept:C0205174 | lld:lifeskim |
| pubmed-article:8354909 | lifeskim:mentions | umls-concept:C0205195 | lld:lifeskim |
| pubmed-article:8354909 | lifeskim:mentions | umls-concept:C0205250 | lld:lifeskim |
| pubmed-article:8354909 | lifeskim:mentions | umls-concept:C1517004 | lld:lifeskim |
| pubmed-article:8354909 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:8354909 | pubmed:dateCreated | 1993-9-21 | lld:pubmed |
| pubmed-article:8354909 | pubmed:abstractText | A combination of low-dose penicillin (75,000 IU/kg twice daily [b.i.d.]) vancomycin (30 mg/kg b.i.d.) and gentamicin (6 mg/kg b.i.d.) has been shown to be as effective as a combination of high-dose penicillin (500,000 IU/kg b.i.d.) and gentamicin (6 mg/kg b.i.d.) in the treatment of rabbit endocarditis caused by an Enterococcus faecium strain moderately resistant to beta-lactams and highly resistant to glycopeptides. The same regimens were evaluated against an E. faecium strain highly resistant to both penicillin (MIC, 128 micrograms/mL) and vancomycin (MIC, 512 micrograms/mL). High doses of penicillin-gentamicin and vancomycin-gentamicin had no effect in in vitro killing-curve studies or in rabbits after treatment for 5 days. High doses of penicillin-vancomycin were only bacteriostatic in killing curves and provided a small reduction in the bacterial titers of the vegetations. In contrast, high-dose penicillin-vancomycin-gentamicin was bactericidal in vitro and highly effective in treating rabbits. However, the emergence of a bacterial subpopulation resistant to the synergistic effect of penicillin and vancomycin could reduce the clinical utility of this combination. | lld:pubmed |
| pubmed-article:8354909 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8354909 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8354909 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:8354909 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8354909 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8354909 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8354909 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8354909 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8354909 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:8354909 | pubmed:issn | 0022-1899 | lld:pubmed |
| pubmed-article:8354909 | pubmed:author | pubmed-author:HumbertGG | lld:pubmed |
| pubmed-article:8354909 | pubmed:author | pubmed-author:LemelandJ FJF | lld:pubmed |
| pubmed-article:8354909 | pubmed:author | pubmed-author:GutmannLL | lld:pubmed |
| pubmed-article:8354909 | pubmed:author | pubmed-author:CaronFF | lld:pubmed |
| pubmed-article:8354909 | pubmed:author | pubmed-author:KlareII | lld:pubmed |
| pubmed-article:8354909 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8354909 | pubmed:volume | 168 | lld:pubmed |
| pubmed-article:8354909 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8354909 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8354909 | pubmed:pagination | 681-6 | lld:pubmed |
| pubmed-article:8354909 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:8354909 | pubmed:meshHeading | pubmed-meshheading:8354909-... | lld:pubmed |
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| pubmed-article:8354909 | pubmed:meshHeading | pubmed-meshheading:8354909-... | lld:pubmed |
| pubmed-article:8354909 | pubmed:meshHeading | pubmed-meshheading:8354909-... | lld:pubmed |
| pubmed-article:8354909 | pubmed:meshHeading | pubmed-meshheading:8354909-... | lld:pubmed |
| pubmed-article:8354909 | pubmed:meshHeading | pubmed-meshheading:8354909-... | lld:pubmed |
| pubmed-article:8354909 | pubmed:meshHeading | pubmed-meshheading:8354909-... | lld:pubmed |
| pubmed-article:8354909 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8354909 | pubmed:articleTitle | Triple combination penicillin-vancomycin-gentamicin for experimental endocarditis caused by a highly penicillin-and glycopeptide-resistant isolate of Enterococcus faecium. | lld:pubmed |
| pubmed-article:8354909 | pubmed:affiliation | Groupe de Recherche en Infections Expérimentales, Hôpital Charles Nicolle, Rouen, France. | lld:pubmed |
| pubmed-article:8354909 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8354909 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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