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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1993-9-21
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pubmed:abstractText |
A combination of low-dose penicillin (75,000 IU/kg twice daily [b.i.d.]) vancomycin (30 mg/kg b.i.d.) and gentamicin (6 mg/kg b.i.d.) has been shown to be as effective as a combination of high-dose penicillin (500,000 IU/kg b.i.d.) and gentamicin (6 mg/kg b.i.d.) in the treatment of rabbit endocarditis caused by an Enterococcus faecium strain moderately resistant to beta-lactams and highly resistant to glycopeptides. The same regimens were evaluated against an E. faecium strain highly resistant to both penicillin (MIC, 128 micrograms/mL) and vancomycin (MIC, 512 micrograms/mL). High doses of penicillin-gentamicin and vancomycin-gentamicin had no effect in in vitro killing-curve studies or in rabbits after treatment for 5 days. High doses of penicillin-vancomycin were only bacteriostatic in killing curves and provided a small reduction in the bacterial titers of the vegetations. In contrast, high-dose penicillin-vancomycin-gentamicin was bactericidal in vitro and highly effective in treating rabbits. However, the emergence of a bacterial subpopulation resistant to the synergistic effect of penicillin and vancomycin could reduce the clinical utility of this combination.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0022-1899
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
168
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
681-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8354909-Animals,
pubmed-meshheading:8354909-Anti-Bacterial Agents,
pubmed-meshheading:8354909-Disease Models, Animal,
pubmed-meshheading:8354909-Drug Resistance, Microbial,
pubmed-meshheading:8354909-Drug Synergism,
pubmed-meshheading:8354909-Drug Therapy, Combination,
pubmed-meshheading:8354909-Endocarditis,
pubmed-meshheading:8354909-Enterococcus faecium,
pubmed-meshheading:8354909-Female,
pubmed-meshheading:8354909-Gentamicins,
pubmed-meshheading:8354909-Gram-Positive Bacterial Infections,
pubmed-meshheading:8354909-Microbial Sensitivity Tests,
pubmed-meshheading:8354909-Penicillin Resistance,
pubmed-meshheading:8354909-Penicillins,
pubmed-meshheading:8354909-Rabbits,
pubmed-meshheading:8354909-Vancomycin
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pubmed:year |
1993
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pubmed:articleTitle |
Triple combination penicillin-vancomycin-gentamicin for experimental endocarditis caused by a highly penicillin-and glycopeptide-resistant isolate of Enterococcus faecium.
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pubmed:affiliation |
Groupe de Recherche en Infections Expérimentales, Hôpital Charles Nicolle, Rouen, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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