Linked Life Data

8203278

Source:http://linkedlifedata.com/resource/pubmed/id/8203278

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1994-7-5
pubmed:abstractText
The effect of oral administration of vanadate (100, 200 and 400 nM for 30 days) on the activity of the detoxifying enzyme system glutathione S-transferase (GST) in rat liver and in several extrahepatic tissues was examined. Vanadate showed a high activity as GST inducer in liver and in small intestine mucosa followed by large intestine mucosa and kidney in a dose-dependent manner. No significant alterations in GST activity were observed in forestomach and lung tissues after vanadate. Vanadate treatment that resulted in an enhancement of GST activity impaired neither hepatic nor renal function as evidenced by serum glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, sorbitol dehydrogenase, urea, and creatinine. Since the ability to induce an increase of detoxifying enzyme activity by anticarcinogenic agents was found to correlate with their activity in the inhibition of tumorigenesis, the trace element vanadium might be considered a potential cancer chemopreventive agent.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0323-9950
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
83-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Selective enhancement of glutathione S-transferase activity in liver and extrahepatic tissues of rat following oral administration of vanadate.
pubmed:affiliation
Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't