Linked Life Data

8155580

Source:http://linkedlifedata.com/resource/pubmed/id/8155580

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
1994-5-19
pubmed:abstractText
The gene crumbs (crb) of Drosophila encodes a transmembrane protein with 30 EGF-like and four laminin A G-domain-like repeats in its extracellular domain. Loss-of-function mutations lead to severe disorganization and degeneration of ectodermally derived embryonic epithelia. In embryos homozygous for crb8F105, an amorphic allele, the CRUMBS protein is diffusely distributed in the cytoplasm instead of being apically localized as in wild-type; this mislocation occurs before any morphologically detectable cellular phenotype becomes manifest, suggesting that apical targeting of proteins is affected in crb mutant embryos. This has been confirmed by using an antibody directed against YELLOW, another apically expressed protein. A single base exchange in crb8F105 leads to the introduction of a premature stop codon, thus eliminating the C-terminal part of the cytoplasmic domain. A possible role for crb in controlling apical-basal polarity is discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0925-4773
pubmed:author
pubmed:issnType
Print
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
175-87
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
CRUMBS is involved in the control of apical protein targeting during Drosophila epithelial development.
pubmed:affiliation
Institut für Entwicklungsbiologie, Universität zu Köln, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't