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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1994-3-23
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pubmed:abstractText |
In vitro cultivated human monocytes show a time-dependent differentiation into macrophages, characterized by an increased expression of macrophage-specific antigens. Monocytes-macrophages were infected with human immunodeficiency virus type 1 strain Ba-L (HIV-1Ba-L) at different stages of differentiation. When 7-day cultured macrophages were infected in the presence of antibodies to beta interferon (IFN-beta), a significant increase in HIV-1 p24 release was detected. This effect was not observed in 1-day monocytes. This finding suggests that IFN-beta secreted by the infected macrophages inhibits p24 release. Treatment of cultured macrophages with recombinant gp120 (rgp120) protein resulted in the induction of IFN-beta mRNA and in an antiviral state to vesicular stomatitis virus. This rgp120-induced antiviral state was largely neutralized by antibodies to IFN-beta, whereas anti-IFN-alpha antibodies were ineffective. In cultured macrophages, 0.1 IU of IFN-beta per ml was sufficient to induce a marked inhibition of vesicular stomatitis virus yield, whereas this dose was ineffective in 1-day monocytes. These results indicate that (i) HIV-1 (possibly in part through its gp120 protein) induces low levels of IFN-beta in macrophages and (ii) this IFN-beta is very effective in inducing an antiviral state in differentiated macrophages.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8107259-1370293,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8107259-1381203,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8107259-1729362,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8107259-1905933,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8107259-1918997,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8107259-1920639,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8107259-1976701,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8107259-2121192,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8107259-2171598,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8107259-2223243,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8107259-2264889,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8107259-2335821,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8107259-2466937,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8107259-2473988,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8107259-2502585,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8107259-2536171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8107259-2550793,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8107259-2784570,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8107259-2844951,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8107259-3014648,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8107259-3277274,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8107259-3772176,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8107259-518835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8107259-6320197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8107259-6961188,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8107259-8345204,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8107259-8392095
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
68
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1983-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8107259-Cell Differentiation,
pubmed-meshheading:8107259-Cells, Cultured,
pubmed-meshheading:8107259-Dose-Response Relationship, Drug,
pubmed-meshheading:8107259-Gene Expression Regulation,
pubmed-meshheading:8107259-HIV Core Protein p24,
pubmed-meshheading:8107259-HIV Envelope Protein gp120,
pubmed-meshheading:8107259-HIV-1,
pubmed-meshheading:8107259-Humans,
pubmed-meshheading:8107259-Interferon Inducers,
pubmed-meshheading:8107259-Interferon-beta,
pubmed-meshheading:8107259-Macrophages,
pubmed-meshheading:8107259-Monocytes,
pubmed-meshheading:8107259-RNA, Messenger,
pubmed-meshheading:8107259-Virus Replication
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pubmed:year |
1994
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pubmed:articleTitle |
Induction of beta interferon by human immunodeficiency virus type 1 and its gp120 protein in human monocytes-macrophages: role of beta interferon in restriction of virus replication.
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pubmed:affiliation |
Department of Virology, Istituto Superiore di Sanita, Rome, Italy.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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