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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
1994-10-13
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pubmed:abstractText |
The association of a biodegradable material and a growth factor could be of clinical value for treating bone defects. We therefore tested the association of transforming growth factor beta (TGF-beta 1) in fibrin glue and coral granules to heal skull defects in rabbits. Adult rabbits underwent a double trepanation symmetrically in both parietal bones. Using histomorphometry, we compared bone repair after 1 month in control animals (n = 5) and in animals treated with either TGF-beta 1 as a single injection of 1 microgram in methylcellulose (n = 5) or in fibrin glue (n = 5), or with coral granules in fibrin glue (n = 4) or with coral granules and TGF-beta 1 1 microgram in fibrin glue (n = 5). We measured the diameter of the remaining defect and the surface of the bone growth. TGF-beta 1 without coral in either methyl cellulose or fibrin induced a partial closure of the defect as assessed by a significant decrease in the defect diameter, compared with the control group. However, the association of TGF-beta 1 in fibrin and coral induced an area of the bone growth higher than in any other groups (P < 0.05). Two months after surgery, this triple association induced a better healing of the defect than coral alone or control group. In each group treated with TGF-beta 1, the mineralization rate was increased not only at the treated side but also in the contralateral defect which was untreated, suggesting a diffusion of the growth factor.(ABSTRACT TRUNCATED AT 250 WORDS)
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0171-967X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
54
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
493-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8082054-Animals,
pubmed-meshheading:8082054-Bone Development,
pubmed-meshheading:8082054-Bone and Bones,
pubmed-meshheading:8082054-Calcium Carbonate,
pubmed-meshheading:8082054-Drug Synergism,
pubmed-meshheading:8082054-Fibrin,
pubmed-meshheading:8082054-Models, Biological,
pubmed-meshheading:8082054-Rabbits,
pubmed-meshheading:8082054-Skull,
pubmed-meshheading:8082054-Surgery, Plastic,
pubmed-meshheading:8082054-Transforming Growth Factor beta,
pubmed-meshheading:8082054-Trephining
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pubmed:year |
1994
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pubmed:articleTitle |
Potentiation of transforming growth factor (TGF-beta 1) by natural coral and fibrin in a rabbit cranioplasty model.
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pubmed:affiliation |
INSERM U349, Centre Viggo Petersen, Paris.
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pubmed:publicationType |
Journal Article,
Comparative Study
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