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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1994-8-25
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pubmed:abstractText |
Calpain activity of nerve growth factor (NGF)-induced rat pheochromocytoma (PC12) cells shows a transient diminution in the early phase of differentiation. Calpain activity can be further decreased by a cell-permeable calpain inhibitor, calpeptin, which enhances the effect of NGF by stimulating neurite elongation. The number of neurites sprouted by one cell is not increased by calpeptin. A possible role of calpain inhibition during PC12 cells' early differentiation is discussed.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0304-3940
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
28
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pubmed:volume |
170
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
91-3
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8041520-Animals,
pubmed-meshheading:8041520-Calpain,
pubmed-meshheading:8041520-Cell Differentiation,
pubmed-meshheading:8041520-Dipeptides,
pubmed-meshheading:8041520-Nerve Growth Factors,
pubmed-meshheading:8041520-Neurites,
pubmed-meshheading:8041520-PC12 Cells,
pubmed-meshheading:8041520-Rats
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pubmed:year |
1994
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pubmed:articleTitle |
Calpeptin, a calpain inhibitor, promotes neurite elongation in differentiating PC12 cells.
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pubmed:affiliation |
Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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