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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1994-8-12
|
| pubmed:abstractText |
These studies have examined the effects of the selective neurokinin1 (NK1) receptor antagonist CP-99,994 on the retching and vomiting response to apomorphine. CP-99,994 (1-3 mg/kg i.p.) attenuated retching and vomiting induced by apomorphine (0.25 mg/kg s.c.) with complete inhibition of retching and vomiting at the 3 mg/kg dose. In contrast CP-100,263 (3 mg/kg i.p.), the enantiomer of CP-99,994 with 1000-fold lower affinity for the NK1 receptor, was without effect.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0028-3908
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
33
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
259-60
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:8035913-Animals,
pubmed-meshheading:8035913-Apomorphine,
pubmed-meshheading:8035913-Dose-Response Relationship, Drug,
pubmed-meshheading:8035913-Ferrets,
pubmed-meshheading:8035913-Male,
pubmed-meshheading:8035913-Piperidines,
pubmed-meshheading:8035913-Receptors, Neurokinin-1,
pubmed-meshheading:8035913-Stereoisomerism,
pubmed-meshheading:8035913-Vomiting
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Enantioselective inhibition of apomorphine-induced emesis in the ferret by the neurokinin1 receptor antagonist CP-99,994.
|
| pubmed:affiliation |
Merck, Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex, U.K.
|
| pubmed:publicationType |
Journal Article
|