Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1994-11-22
pubmed:abstractText
We analyzed the transcription and release of interleukin-8 (IL-8) from human polymorphonuclear granulocytes (PMNs) and a lymphocyte-monocyte-basophil (LMB) cell population stimulated for different time periods (30 min to 16 h) with pore-forming bacterial toxins (Panton-Valentine leukocidin [Luk-PV] and alveolysin [Alv]) as well as with the erythrogenic toxin A (ETA) as a superantigen. At high toxin concentrations (500 ng/10(7) cells), Luk-PV and Alv led to a decreased IL-8 generation from LMBs within the first 30 min; with PMNs, a slight increase in IL-8 release was observed. Under these conditions, stimulation with ETA did not lead to an altered cellular IL-8 release. At lower concentrations (5 and 0.5 ng/10(7) cells), all three toxins led to a continuous increase (over 16 h) in IL-8 release and IL-8 mRNA expression of PMNs and LMBs. Preincubation of the cells with the protein tyrosine kinase inhibitors lavendustin A and tyrphostin 25 led to a reduction of the toxin-mediated effects on IL-8 release and IL-8 mRNA expression when Luk-PV and Alv were used as stimuli. In contrast, IL-8 synthesis in cells which were stimulated with ETA was not influenced by protein tyrosine kinase inhibition. From our data, one may suggest that multiple pathways for IL-8 production are operative in human leukocytes.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/7927762-13426414, http://linkedlifedata.com/resource/pubmed/commentcorrection/7927762-13845860, http://linkedlifedata.com/resource/pubmed/commentcorrection/7927762-1426765, http://linkedlifedata.com/resource/pubmed/commentcorrection/7927762-1455512, http://linkedlifedata.com/resource/pubmed/commentcorrection/7927762-1590989, http://linkedlifedata.com/resource/pubmed/commentcorrection/7927762-1639472, http://linkedlifedata.com/resource/pubmed/commentcorrection/7927762-1903412, http://linkedlifedata.com/resource/pubmed/commentcorrection/7927762-1958289, http://linkedlifedata.com/resource/pubmed/commentcorrection/7927762-2068381, http://linkedlifedata.com/resource/pubmed/commentcorrection/7927762-2185544, http://linkedlifedata.com/resource/pubmed/commentcorrection/7927762-2440339, http://linkedlifedata.com/resource/pubmed/commentcorrection/7927762-2451254, http://linkedlifedata.com/resource/pubmed/commentcorrection/7927762-2524876, http://linkedlifedata.com/resource/pubmed/commentcorrection/7927762-2552117, http://linkedlifedata.com/resource/pubmed/commentcorrection/7927762-2642470, http://linkedlifedata.com/resource/pubmed/commentcorrection/7927762-2866160, http://linkedlifedata.com/resource/pubmed/commentcorrection/7927762-2901352, http://linkedlifedata.com/resource/pubmed/commentcorrection/7927762-2992362, http://linkedlifedata.com/resource/pubmed/commentcorrection/7927762-3152763, http://linkedlifedata.com/resource/pubmed/commentcorrection/7927762-3260265, http://linkedlifedata.com/resource/pubmed/commentcorrection/7927762-3283239, http://linkedlifedata.com/resource/pubmed/commentcorrection/7927762-3781620, http://linkedlifedata.com/resource/pubmed/commentcorrection/7927762-4024147, http://linkedlifedata.com/resource/pubmed/commentcorrection/7927762-4044030, http://linkedlifedata.com/resource/pubmed/commentcorrection/7927762-4179068, http://linkedlifedata.com/resource/pubmed/commentcorrection/7927762-6273325, http://linkedlifedata.com/resource/pubmed/commentcorrection/7927762-6274802, http://linkedlifedata.com/resource/pubmed/commentcorrection/7927762-6323315, http://linkedlifedata.com/resource/pubmed/commentcorrection/7927762-6411708, http://linkedlifedata.com/resource/pubmed/commentcorrection/7927762-6778510, http://linkedlifedata.com/resource/pubmed/commentcorrection/7927762-7003609, http://linkedlifedata.com/resource/pubmed/commentcorrection/7927762-8380937, http://linkedlifedata.com/resource/pubmed/commentcorrection/7927762-8381770, http://linkedlifedata.com/resource/pubmed/commentcorrection/7927762-8436597, http://linkedlifedata.com/resource/pubmed/commentcorrection/7927762-8478031
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Proteins, http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers, http://linkedlifedata.com/resource/pubmed/chemical/Exotoxins, http://linkedlifedata.com/resource/pubmed/chemical/Hemolysin Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-8, http://linkedlifedata.com/resource/pubmed/chemical/Leukocidins, http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Nitriles, http://linkedlifedata.com/resource/pubmed/chemical/Organic Chemicals, http://linkedlifedata.com/resource/pubmed/chemical/Phenols, http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases, http://linkedlifedata.com/resource/pubmed/chemical/SpeA protein, Streptococcus pyogenes, http://linkedlifedata.com/resource/pubmed/chemical/Tyrphostins, http://linkedlifedata.com/resource/pubmed/chemical/alveolysin, http://linkedlifedata.com/resource/pubmed/chemical/erythrogenic toxin, http://linkedlifedata.com/resource/pubmed/chemical/lavendustin A, http://linkedlifedata.com/resource/pubmed/chemical/tyrphostin 25
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0019-9567
pubmed:author
pubmed:issnType
Print
pubmed:volume
62
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4831-7
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
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