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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1994-1-25
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pubmed:abstractText |
ICAM-1 expression was studied on alveolar macrophages (AM) in extrinsic allergic alveolitis (EAA) using immunocytochemistry and cytometry. Compared to control donors, EAA patients had higher percentages of ICAM-1+ AM (75% vs. 30%) and the antigen density was more than sixfold higher (673 vs. 103 channels). Levels of soluble serum ICAM-1 were found increased in EAA patients with an average of 866.2 +/- 300 ng/ml versus 394.8 +/- 110 ng/ml in controls. These data are consistent with the concept that antigen contact upregulates ICAM-1 expression on AM in EAA followed by shedding and an increase in serum sICAM-1.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0025-7931
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
221-6
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pubmed:dateRevised |
2009-11-11
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pubmed:meshHeading |
pubmed-meshheading:7903468-Adult,
pubmed-meshheading:7903468-Aged,
pubmed-meshheading:7903468-Alveolitis, Extrinsic Allergic,
pubmed-meshheading:7903468-Antigens, CD,
pubmed-meshheading:7903468-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:7903468-Cell Adhesion Molecules,
pubmed-meshheading:7903468-Female,
pubmed-meshheading:7903468-Humans,
pubmed-meshheading:7903468-Intercellular Adhesion Molecule-1,
pubmed-meshheading:7903468-Macrophages, Alveolar,
pubmed-meshheading:7903468-Male,
pubmed-meshheading:7903468-Middle Aged
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pubmed:year |
1993
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pubmed:articleTitle |
Expression of the adhesion molecule ICAM-1 on alveolar macrophages and in serum in extrinsic allergic alveolitis.
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pubmed:affiliation |
Department of Internal Medicine, Klinikum Innenstadt, University of Munich, FRG.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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