Linked Life Data

7891041

Source:http://linkedlifedata.com/resource/pubmed/id/7891041

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
Pt 1
pubmed:dateCreated
1995-4-17
pubmed:abstractText
The physiological actions of lobster peptide F1 (TNRNFLRFamide) have been examined on three different lobster nerve-muscle preparations (exoskeletal, cardiac and visceral). The peptide, which is found at high concentrations in a lobster neurosecretory gland, causes a long-lasting enhancement of contractility in each target tissue. On exoskeletal nerve-muscle preparations, peptide F1 has the following actions: (1) it potentiates transmitter release from nerve terminals innervating exoskeletal muscle, leading to an increase in both spontaneous and nerve-evoked release of transmitter; (2) it acts directly on the muscle, in the absence of nerve activity, to induce tonic contractions; and (3) it shows a potent desensitization that does not reverse with prolonged washing of the tissue. On each of the types of muscle examined, peptide F1 is active at nanomolar concentrations and is 3-4 orders of magnitude more potent than FMRFamide. These findings suggest that peptide F1 is a neurohormone with widespread myogenic actions throughout lobster peripheral tissues. The molecular mechanism(s) by which the peptide acts are not yet known, but do not appear to involve cyclic AMP or cyclic GMP.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0022-0949
pubmed:author
pubmed:issnType
Print
pubmed:volume
198
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
97-108
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Peptide F1, an N-terminally extended analog of FMRFamide, enhances contractile activity in multiple target tissues in lobster.
pubmed:affiliation
Department of Molecular Physiology, University of Virginia Health Sciences Center, Charlottesville 22908.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.