Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1995-3-3
pubmed:abstractText
Two virus-inducible transcription factors, IRF-1 and IRF-2 have been identified as an activator and a repressor, respectively, of the type I interferon (IFN) genes. Recent studies with mice carrying null mutations for the IRF-1 or IRF-2 alleles have revealed the existence of IRF-1-dependent and -independent pathways mediating IFN-beta gene induction. Here we report that the expression of an IRF family member ISGF3 gamma is induced upon viral infection in IRF-1-/-, IRF-2-/- embryonic fibroblasts. Furthermore, ISGF3 gamma can bind to a virus-inducible promoter element in the IFN-beta gene. These results suggest that ISGF3 gamma or complex containing ISGF3 gamma is involved in the IRF-1-independent pathway mediating IFN-beta gene regulation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0014-5793
pubmed:author
pubmed:issnType
Print
pubmed:day
30
pubmed:volume
358
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
225-9
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:7843405-Amino Acid Sequence, pubmed-meshheading:7843405-Animals, pubmed-meshheading:7843405-Base Sequence, pubmed-meshheading:7843405-Cells, Cultured, pubmed-meshheading:7843405-DNA-Binding Proteins, pubmed-meshheading:7843405-Gene Expression Regulation, Viral, pubmed-meshheading:7843405-HeLa Cells, pubmed-meshheading:7843405-Humans, pubmed-meshheading:7843405-Interferon-Stimulated Gene Factor 3, pubmed-meshheading:7843405-Interferon-Stimulated Gene Factor 3, gamma Subunit, pubmed-meshheading:7843405-Interferon-beta, pubmed-meshheading:7843405-Mice, pubmed-meshheading:7843405-Molecular Sequence Data, pubmed-meshheading:7843405-Newcastle disease virus, pubmed-meshheading:7843405-RNA, Messenger, pubmed-meshheading:7843405-Sequence Homology, Amino Acid, pubmed-meshheading:7843405-Transcription Factors, pubmed-meshheading:7843405-Transcriptional Activation
pubmed:year
1995
pubmed:articleTitle
Possible involvement of the transcription factor ISGF3 gamma in virus-induced expression of the IFN-beta gene.
pubmed:affiliation
Institute for Molecular and Cellular Biology, Osaka University, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't