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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5135
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pubmed:dateCreated |
1993-12-8
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pubmed:databankReference |
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pubmed:abstractText |
Although presentation of antigen to the T cell receptor is necessary for the initiation of an immune response, additional molecules expressed on antigen-presenting cells deliver essential costimulatory signals. T cell activation, in the absence of costimulation, results in T cell anergy. The B7-1 protein is a costimulator molecule that regulates interleukin-2 (IL-2) secretion by signaling through the pathway that uses CD28 and CTLA-4 (hereafter referred to as the CD28 pathway). We have cloned a counter-receptor of CD28 and CTLA-4, termed B7-2. Although only 26 percent identical to B7-1, B7-2 also costimulates IL-2 production and T cell proliferation. Unlike B7-1, B7-2 messenger RNA is constitutively expressed in unstimulated B cells. It is likely that B7-2 provides a critical early costimulatory signal determining if the T cell will contribute to an immune response or become anergic.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD28,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD80,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD86,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/CD86 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA-4 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoconjugates,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/abatacept
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
262
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
909-11
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:7694363-Amino Acid Sequence,
pubmed-meshheading:7694363-Animals,
pubmed-meshheading:7694363-Antigens, CD,
pubmed-meshheading:7694363-Antigens, CD28,
pubmed-meshheading:7694363-Antigens, CD80,
pubmed-meshheading:7694363-Antigens, CD86,
pubmed-meshheading:7694363-Antigens, Differentiation,
pubmed-meshheading:7694363-B-Lymphocytes,
pubmed-meshheading:7694363-CTLA-4 Antigen,
pubmed-meshheading:7694363-Cell Line,
pubmed-meshheading:7694363-Cloning, Molecular,
pubmed-meshheading:7694363-DNA, Complementary,
pubmed-meshheading:7694363-Humans,
pubmed-meshheading:7694363-Immunoconjugates,
pubmed-meshheading:7694363-Lymphocyte Activation,
pubmed-meshheading:7694363-Membrane Glycoproteins,
pubmed-meshheading:7694363-Molecular Sequence Data,
pubmed-meshheading:7694363-Sequence Alignment,
pubmed-meshheading:7694363-Signal Transduction,
pubmed-meshheading:7694363-T-Lymphocytes
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pubmed:year |
1993
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pubmed:articleTitle |
Cloning of B7-2: a CTLA-4 counter-receptor that costimulates human T cell proliferation.
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pubmed:affiliation |
Division of Hematologic Malignancies, Dana-Farber Cancer Institute.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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