Source:http://linkedlifedata.com/resource/umls/id/C0111208
MSH: An inhibitory T CELL receptor that is closely related to CD28 ANTIGEN. It has specificity for CD80 ANTIGEN and CD86 ANTIGEN and acts as a negative regulator of peripheral T cell function. CTLA-4 antigen is believed to play role in inducing PERIPHERAL TOLERANCE.,NCI: CTLA-4 is an inhibitory T-cell surface receptor for B7 ligands on antigen presenting cells. It contains an extracellular V-like domain, a transmembrane region, and a putative cytoplasmic domain. It shares significant homology with CD28. Both bind the same ligands, however CTLA-4 binds to B7 with a greater affinity. B7 antigen-presenting cells regulate T-cell activation by delivering antigen-independent stimulatory signals through CD28 and inhibitory signals through CTLA-4. While CD28 is on the membrane of resting T-cells, CTLA-4 is detectable only on cells activated after antigen presentation. A CTLA-4 splice variant with a deleted transmembrane segment is preferentially expressed in non-activated T-cells. Activation of lymphocytes results in