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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
15
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pubmed:dateCreated |
1993-9-7
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pubmed:abstractText |
Ligand-stimulated autophosphorylation of the platelet-derived growth factor receptor (PDGFR) beta subunit creates a number of binding sites for SH2-containing proteins. One of the PDGFR-associated proteins is a 64-kDa protein of unknown identity and function. We present data indicating that the 64-kDa protein that associates with the activated PDGFR is Syp (also called SH-PTP2, PTP-1D, or SH-PTP3), the ubiquitously expressed 64-kDa SH2-containing protein-tyrosine phosphatase. Phosphorylation of Tyr-1009 in the C terminus of the PDGFR is required for the stable association of Syp, suggesting that phosphorylation of this residue creates a binding site for the Syp SH2 domains. Although Syp stably associates with the PDGFR, this event is not required for PDGF-stimulated tyrosine phosphorylation of Syp. These data raise the interesting possibility that protein-tyrosine phosphatases contribute to the intracellular relay of biological signals originating from receptor tyrosine kinases such as the PDGFR.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688466-1280823,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688466-1281790,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688466-1310893,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688466-1312663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688466-1314164,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688466-1322798,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688466-1333047,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688466-1372091,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688466-1372395,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688466-1373816,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688466-1374684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688466-1375321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688466-1396585,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688466-1638629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688466-1648262,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688466-1652101,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688466-1653029,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688466-1691440,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688466-1696179,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688466-1732748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688466-1736296,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688466-1846320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688466-1979659,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688466-2156626,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688466-2164155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688466-2166336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688466-2170111,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688466-2173144,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688466-2452172,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688466-2466336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688466-2479827,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688466-2550143,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688466-2550144,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688466-2550789,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688466-2554305,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688466-7680959,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688466-7681217,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688466-7682895,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688466-8096088,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688466-8382774,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688466-8443409
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Macromolecular Substances,
http://linkedlifedata.com/resource/pubmed/chemical/PTPN11 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/PTPN6 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphotyrosine,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Tyrosine Phosphatase...,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Tyrosine Phosphatase...,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Tyrosine Phosphatases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Platelet-Derived Growth...,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
90
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pubmed:geneSymbol |
Syp
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6939-43
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:7688466-Humans,
pubmed-meshheading:7688466-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:7688466-Macromolecular Substances,
pubmed-meshheading:7688466-Peptide Mapping,
pubmed-meshheading:7688466-Phosphorylation,
pubmed-meshheading:7688466-Phosphotyrosine,
pubmed-meshheading:7688466-Protein Binding,
pubmed-meshheading:7688466-Protein Tyrosine Phosphatase, Non-Receptor Type 11,
pubmed-meshheading:7688466-Protein Tyrosine Phosphatase, Non-Receptor Type 6,
pubmed-meshheading:7688466-Protein Tyrosine Phosphatases,
pubmed-meshheading:7688466-Receptors, Platelet-Derived Growth Factor,
pubmed-meshheading:7688466-Tumor Cells, Cultured,
pubmed-meshheading:7688466-Tyrosine
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pubmed:year |
1993
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pubmed:articleTitle |
The 64-kDa protein that associates with the platelet-derived growth factor receptor beta subunit via Tyr-1009 is the SH2-containing phosphotyrosine phosphatase Syp.
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pubmed:affiliation |
National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.
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