Linked Life Data

7643221

Source:http://linkedlifedata.com/resource/pubmed/id/7643221

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1995-9-20
pubmed:abstractText
Drosophila bang-sensitive paralytic mutants suffer from hyperactivity and paralysis following a mechanical shock; after recovery from paralysis, they cannot be paralyzed for a refractory period lasting up to 1 hr. Previously, we have shown that in easily shocked (eas), a typical bang-sensitive mutant, electrical shocks delivered to the brain cause seizure-like activity in the dorsal longitudinal flight motor neurons (DLMmns), and failure of giant fiber (GF) stimulation to evoke DLM potentials via the escape response pathway (Pavlidis et al., 1994). Here, we show that seizure and failure in the GF pathway with a refractory period is common to all six members of the bang-sensitive class. This syndrome was not found in any of eight other excitability mutants, including those affecting voltage-gated sodium or potassium-channel function. We show that failure occurs at the synapse between a peripherally synapsing interneuron (PSI) and the DLMmns, while the DLMmn-DLM neuromuscular junctions remain functional. Additionally, failure occurs in all other GF pathway-activated muscles. Failures occurred without seizures in the tergotrochanteral jump muscle (TTM), as was also found in approximately 10% of DLM tests, suggesting that seizures and failures may be independent events. This hypothesis is supported by the finding that, in double mutant combination with mlenapts, which suppresses behavioral bang sensitivity, DLM failures, but not seizures, were reduced.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0270-6474
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5810-9
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Seizures and failures in the giant fiber pathway of Drosophila bang-sensitive paralytic mutants.
pubmed:affiliation
Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.