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| pubmed-article:7586747 | lifeskim:mentions | umls-concept:C0206116 | lld:lifeskim |
| pubmed-article:7586747 | lifeskim:mentions | umls-concept:C0007585 | lld:lifeskim |
| pubmed-article:7586747 | lifeskim:mentions | umls-concept:C0040690 | lld:lifeskim |
| pubmed-article:7586747 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:7586747 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:7586747 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:7586747 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:7586747 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:7586747 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:7586747 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:7586747 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:7586747 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:7586747 | pubmed:dateCreated | 1995-12-28 | lld:pubmed |
| pubmed-article:7586747 | pubmed:abstractText | Tumor necrosis factor (TNF)-alpha and transforming growth factor (TGF)-beta produced by glial cells have been proposed bo play a role in various neurodenegerative diseases. The interaction of these two cytokines, however, is unknown. We tested the hypothesis that the TNF-alpha released from lipopolysaccharide (LPS)-treated murine microglial cells would stimulate the release of TGF-beta, which in turn would control TNF-alpha production. Treatment of murine microglial cell cultures with LPS resulted in an acute release of TNF-alpha (peak by 8 hr) followed by delayed release of bioactive TGF-beta (peak by 48 hr). Anti-TNF-alpha antibody significantly inhibited LPS-stimulated TGF-beta production, suggesting the involvement of TNF-alpha in TGF-beta production. Also, exogenous TNF-alpha induced in a dose-dependent fashion microglial cell expression of TGF-beta 1 mRNA and release of TGF-beta. Exogenous TGF-beta, on the other hand, suppressed LPS-stimulated TNF-alpha release. These findings suggest an autoregulation of microglial cell TNF-alpha production by TGF-beta which may limit inflammation-associated brain injury. | lld:pubmed |
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| pubmed-article:7586747 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:7586747 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7586747 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7586747 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:7586747 | pubmed:issn | 0090-1229 | lld:pubmed |
| pubmed-article:7586747 | pubmed:author | pubmed-author:PetersonP KPK | lld:pubmed |
| pubmed-article:7586747 | pubmed:author | pubmed-author:HoYY | lld:pubmed |
| pubmed-article:7586747 | pubmed:author | pubmed-author:ChaoC CCC | lld:pubmed |
| pubmed-article:7586747 | pubmed:author | pubmed-author:TsangMM | lld:pubmed |
| pubmed-article:7586747 | pubmed:author | pubmed-author:ShengW SWS | lld:pubmed |
| pubmed-article:7586747 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7586747 | pubmed:volume | 77 | lld:pubmed |
| pubmed-article:7586747 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7586747 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7586747 | pubmed:pagination | 358-65 | lld:pubmed |
| pubmed-article:7586747 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:7586747 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7586747 | pubmed:articleTitle | Tumor necrosis factor-alpha mediates the release of bioactive transforming growth factor-beta in murine microglial cell cultures. | lld:pubmed |
| pubmed-article:7586747 | pubmed:affiliation | Minneapolis Medical Research Foundation, Department of Medicine, Hennepin County Medical Center, Minnesota, USA. | lld:pubmed |
| pubmed-article:7586747 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7586747 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7586747 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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