Linked Life Data

7581721

Source:http://linkedlifedata.com/resource/pubmed/id/7581721

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1995-12-13
pubmed:abstractText
Pgp-1 expression was studied as a marker of memory/activation on systemic and mucosal T cells of BALB/c and C57BL/6 mice after infection with respiratory syncytial virus (RSV), using two-color dual fluorescence flow cytometry employing anti-L3T4 (CD4), anti-Ly2 (CD8), and anti-Pgp-1 (CD44) monoclonal antibodies. Pgp-1 was expressed in relatively low densities on T cells of C57BL/6 mice, allowing differentiation of a dual population of Pgp-1(10) and Pgp-1hi T cells after antigenic stimulation in vivo. On the contrary, T cells of BALB/c mice were uniformly Pgp-1hi, making this mouse strain less suitable for studies with this marker. In blood and spleen consistently more CD8+ than CD4+ T cells were Pgp-1hi, while in BAL more CD4+ than CD8+ T cells were Pgp-1hi. After primary but not after secondary infection, CD4+ Pgp-1hi T cells increased significantly in the blood and spleen. After secondary infection both CD4+ Pgp-1hi and CD8+ Pgp-1hi T cells increased in the BAL. It is hypothesized that after primary infection systemic RSV-specific T cells acquire an activation/memory phenotype as characterized by an enhanced expression of Pgp-1, resulting in a faster and stronger influx of these cells in the lungs after secondary infection.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0905-6157
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
119-23
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Mucosal T cells recovered from mice after infection with respiratory syncytial virus display a memory/activation phenotype.
pubmed:affiliation
Beatrix Children's Hospital, University Hospital, Groningen, The Netherlands.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't