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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1995-7-13
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pubmed:abstractText |
It has recently been shown that mice deficient in the gene for myelin-associated glycoprotein develop normal myelin sheaths in the peripheral nervous system. Here we report that in mutant mice older than 8 months the maintenance of axon-myelin units is disturbed, resulting in both axon and myelin degeneration. Morphological features include those typically seen in human peripheral neuropathies, where demyelination-induced Schwann cell proliferation and remyelination lead to the formation of so-called onion bulbs. Expression of tenascin-C, a molecule indicative of peripheral nerve degeneration, was up-regulated by axon-deprived Schwann cells and regenerating axons were occasionally seen. Myelin-associated glycoprotein thus appears to play a crucial role in the long-term maintenance of the integrity of both myelin and axons.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0953-816X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
511-5
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7539694-Animals,
pubmed-meshheading:7539694-Axons,
pubmed-meshheading:7539694-Brachial Plexus,
pubmed-meshheading:7539694-Cell Adhesion Molecules, Neuronal,
pubmed-meshheading:7539694-Extracellular Matrix Proteins,
pubmed-meshheading:7539694-Femoral Nerve,
pubmed-meshheading:7539694-Fluorescent Antibody Technique,
pubmed-meshheading:7539694-Mice,
pubmed-meshheading:7539694-Mice, Knockout,
pubmed-meshheading:7539694-Microscopy, Electron,
pubmed-meshheading:7539694-Microscopy, Immunoelectron,
pubmed-meshheading:7539694-Myelin Proteins,
pubmed-meshheading:7539694-Myelin Sheath,
pubmed-meshheading:7539694-Myelin-Associated Glycoprotein,
pubmed-meshheading:7539694-Nerve Tissue Proteins,
pubmed-meshheading:7539694-Sciatic Nerve,
pubmed-meshheading:7539694-Tenascin
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pubmed:year |
1995
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pubmed:articleTitle |
Crucial role for the myelin-associated glycoprotein in the maintenance of axon-myelin integrity.
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pubmed:affiliation |
Department of Neurobiology, Swiss Federal Institute of Technology, Hönggerberg, Zurich.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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