Linked Life Data

7536759

Source:http://linkedlifedata.com/resource/pubmed/id/7536759

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1995-5-24
pubmed:abstractText
It has been speculated elsewhere that growth factors produced by macrophages in response to tissue damage induce a modulation of pre-existing fibroblasts into myofibroblasts, leading to fibrosis. The development of these cells in cis-diamminedichloroplatinum (CDDP)-induced rat renal interstitial fibrosis was observed immunohistochemically. In the cortico-medullary junction, nuclear changes and epithelial necrosis of the proximal renal tubule (mainly the P3 segment) were seen on days 1 and 4 after a single dose (6 mg/kg body weight) of CDDP, and regenerating epithelium appeared on day 7. Gradually developing fibrosis was observed around the affected tubules on days 14 and 28. The increase in fibrosis was confirmed by histometrical analysis. The number of ED-1 (primary antibody) positive macrophages reached a peak in the affected cortico-medullary junction on day 7 and this was accompanied by an increase in muscle actin-positive myofibroblasts. On days 14 and 28, macrophages had declined in number, but the number of muscle actin-positive myofibroblasts in the fibrotic area was still high as compared with control values. Cytoplasmic myofilaments were observed in myofibroblasts by electron microscopy. These findings suggest that the myofibroblasts participate in renal interstitial fibrosis in the rat, and that their appearance may be related to macrophage infiltration in response to tubular injury, at least in the early stages of fibrosis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0021-9975
pubmed:author
pubmed:issnType
Print
pubmed:volume
112
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
27-39
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Immunohistochemical observations on the kinetics of macrophages and myofibroblasts in rat renal interstitial fibrosis induced by cis-diamminedichloroplatinum.
pubmed:affiliation
Department of Veterinary Pathology, College of Agriculture, University of Osaka Prefecture, Japan.
pubmed:publicationType
Journal Article