Linked Life Data

7423531

Source:http://linkedlifedata.com/resource/pubmed/id/7423531

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1980-12-18
pubmed:abstractText
The activities of the enzymes superoxide dismutase, catalase and glutathione peroxidase increase in the lungs of neonatal rats exposed to normobaric hyperoxia. The oxygen-mediated increase in activity of these enzymes, known from previous studies to be an inductive response, was studied in 10- and 25-day-old rats as a function of both oxygen concentration and length of time of exposure to greater than 95% oxygen. In the lungs of 10-day-old rats the increase in superoxide dismutase, catalase, and glutathione peroxidase occurs only at 80% ambient oxygen or greater. In 25-day-old rats a similar pattern of response occurs with pulmonary catalase and glutathione peroxidase. However, unlike the response in 10-day-old rats, pulmonary superoxide dismutase does not increase in oxygen-exposed 25-day-old rats. The time course of enzyme induction was different for 10-day-old rats compared with 25-day-old rats. Exposure of 10-day-old rats to 95+% oxygen resulted in a significant increase in activity of superoxide dismutase after only 4 h when compared with air-exposed control animals. Catalasee and glutathione peroxidase in the same age group increased significantly after 6 h and 12 h of exposure to oxygen, respectively. Maximal levels of superoxide dismutase, catalase and glutathione peroxidase were reached after 6, 12 and 24 h of exposure to hyperoxia, respectively. This level of activity was then maintained throughout the subsequent exposure time up to 96 h. The activity of pulmonary catalase and glutathione peroxidase in 25-day-old rats did not increase significantly after 6 h of exposure to hyperoxia. An apparent plateau of increased activity was reached after 24 h of exposure. As observed with the 3 enzymes in 10-day-old rats, maximal enzyme activities were maintained throughout the subsequent period of oxygen exposure up to 96 h.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0300-483X
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
215-25
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Adaptation to hyperoxia in the neonatal rat: kinetic parameters of the oxygen-mediated induction of lung superoxide dismutases, catalase and glutathione peroxidase.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.