Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1982-2-12
|
| pubmed:abstractText |
In vivo administration of mitomycin C (MMC) to C57BL/6J mice induced a rapid, initial suppression (24 hours post injection) of in vitro mitogenesis. This was followed by of the mitogen concentration-response curves were found of the three mitogens, phytohemagglutinin and concanavalin A, but not for lipopolysaccharide. By 144 hours post injection, the dose-response curves and magnitude of the responses had returned to approximately control (untreated) levels. This approach provides a model system for the functional assessment of in vivo cellular damage by MMC.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0047-6374
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
17
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
195-201
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:7311624-Animals,
pubmed-meshheading:7311624-Cell Division,
pubmed-meshheading:7311624-Concanavalin A,
pubmed-meshheading:7311624-Crossing Over, Genetic,
pubmed-meshheading:7311624-Dose-Response Relationship, Drug,
pubmed-meshheading:7311624-Lipopolysaccharides,
pubmed-meshheading:7311624-Mice,
pubmed-meshheading:7311624-Mice, Inbred C57BL,
pubmed-meshheading:7311624-Mitomycins,
pubmed-meshheading:7311624-Phytohemagglutinins,
pubmed-meshheading:7311624-Sister Chromatid Exchange,
pubmed-meshheading:7311624-Spleen
|
| pubmed:year |
1981
|
| pubmed:articleTitle |
Relationship between in vivo mitomycin C exposure, sister chromatid exchange induction and in vitro mitogenic proliferation. I. Development of murine splenic cell system.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|