Linked Life Data

6997818

Source:http://linkedlifedata.com/resource/pubmed/id/6997818

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1980-11-24
pubmed:abstractText
Circulating arginine vasopressin (AVP) and plasma renin activity responses to furosemide (2 mg/kg) and acute hypertonic saline (10 mEq/kg) were studied in the fetal lamb from 100 days gestation to term. The baseline to peak plasma AVP response (delta 3.7 +/- 1.2 uU/ml) and area under the response curve (209 +/- 57 uU/ml/65 min) in the fetal lambs > 123 days were greater than in those < 106 days gestation (delta 1.8 +/0 1.1 and (171 +/- 61, respectively), P < 0.02. The plasma renin activity/AVP ratio after furosemide was similar in the two gestational groups. The log plasma AVP responses corrected for rise in plasma osmolality (0.090 +/- .01 uU/ml) 30 min after infusion, and the area under the response curve (253 +/- 49 uU/ml/30 min) was greater (P < 0.02) in the fetal lambs > 120 days than in those under 115 days gestation (.035 +/0 0.01 and 88 +/0 29, respectively), P < 0.02. These results confirm that the fetal lamb responds to an osmotic stimulus with increased plasma AVP levels and documents that this response significantly matures during the last trimester of gestation. The fetal lamb also manifests a hypothalamus-posterior pituitary AVP response to furosemide that is proportional to the maturing renal renin response.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0031-3998
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
869-71
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Effects of furosemide and acute salt loading on vasopressin and renin secretion in the fetal lamb.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.