Linked Life Data

6962021

Source:http://linkedlifedata.com/resource/pubmed/id/6962021

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1983-4-15
pubmed:abstractText
We have used the kindling paradigm at the spinal cord level. In spinal, unanaesthetized, paralysed (gallamine 20 mg/kg) cats, the cutaneous afferent (sural) or the muscle afferent (gastrocnemius, tibial and peroneal) nerves were electrically stimulated at 20 min intervals with a 3 sec train (100 Hz, 2 msec pulse duration, 200-400 microA). Kindling was assessed by averaging 16 mono- or polysynaptic ventral root reflex responses produced by constant intensity single shocks. Atropine sulphate (0.5 mg/kg) and naloxone (0.4 mg/kg) effects were measured in the kindled preparation. Kindling induced a progressive increment of the amplitude, ipsilateral propagation and after-discharge frequency. This was greater in polysynaptic responses. When testing monosynaptic responses during the kindling of cutaneous afferents, a cumulative inhibitory effect was observed. In both types of kindled response, atropine had a transient inhibitory effect. Naloxone noticeably augmented the kindled polysynaptic reflexes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0424-8155
pubmed:author
pubmed:issnType
Print
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
257-63
pubmed:dateRevised
2007-10-8
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Kindling in the spinal cord: differential effects on mono- and polysynaptic reflexes and its modifications by atropine and naloxone.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't