Linked Life Data

6820374

Source:http://linkedlifedata.com/resource/pubmed/id/6820374

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1983-6-10
pubmed:abstractText
The effect of pinealectomy on the circadian periodicity in plasma gonadotropins (LH and FSH), testosterone (T) and dihydrotestosterone (DHT) was investigated in adult male rats maintained under conditions of 12 h light/12 h dark (light on 06:00-18:00 h). Animals were killed at 3 hour intervals over 24 hours by decapitation. Plasma concentrations of LH, T and DTH (but not FSH) were found to exhibit significant circadian variations as determined by analysis of variance. No distinct LH or T nadir was recorded but peaks were observed at 09:00 h. Peak DHT values were recorded near the middle of the dark period. Pinealectomy resulted in an altered daily LH and T rhythmicity, and also in an abolished DHT rhythmicity. The fact that there was no significant increase in mean gonadotropin levels at 50 days after pinealectomy suggests that the pineal regulates the timing of gonadotropin secretion rather than the quantity. Since pinealectomy was found to abolish the circadian rhythm of DHT but not of T, we deduced that the pineal may also be responsible for the rhythmic conversion of T to DHT.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0391-4097
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
397-401
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Influence of pinealectomy on circadian patterns of plasma luteinizing hormone, follicle-stimulating hormone, testosterone and dihydrotestosterone in the male rat.
pubmed:publicationType
Journal Article, Comparative Study