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rdf:type |
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lifeskim:mentions |
umls-concept:C0003250,
umls-concept:C0005768,
umls-concept:C0007634,
umls-concept:C0019409,
umls-concept:C0040300,
umls-concept:C0205307,
umls-concept:C0205332,
umls-concept:C0348080,
umls-concept:C0442726,
umls-concept:C1412716,
umls-concept:C1511790,
umls-concept:C1704711,
umls-concept:C1709160
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pubmed:issue |
1
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pubmed:dateCreated |
1984-9-19
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pubmed:abstractText |
When studied with double staining techniques HNK-1+ cells include subsets not expressing T cell antigens (A), expressing T8 antigens (B) and expressing T4 antigens (C). Cells with phenotype A are observed as the dominant HNK-1+ population (greater than 50% of all HNK-1+ cells) in the blood from controls and from patients with solid tumours, infectious mononucleosis and sarcoidosis. Cells with phenotype B are always a substantial subset (35% of HNK-1+ cells) in the peripheral blood but in patients with B chronic lymphocytic leukaemia and angioimmunoblastic lymphadenopathy these cells are present in an even higher percentage (greater than 50% of all HNK-1+ cells). This cell subset is the only HNK-1+ population found in the few tumour samples where HNK-1+ cells are identifiable. Apart from these few cases of malignancies, the type A and B subsets are rare in the tissues. In these samples Leu 11+ cells seem to be absent. In contrast, cells with phenotype C are a minor population in the blood but represent most HNK-1+ cells in the germinal centres of lymph nodes and their malignant counterparts in follicular centre cell lymphoma. These HNK-1+, T4+ cells are Leu 11-. These phenotypic characteristics indicate that the most efficient NK cells may represent a circulating and not a tissue seeking population.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6744669-285769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6744669-367949,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6744669-6101787,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6744669-6166701,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6744669-6173418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6744669-6180009,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6744669-6185544,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6744669-6189181,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6744669-6211202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6744669-6218202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6744669-6219848,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6744669-6221840,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6744669-6225799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6744669-6352107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6744669-6459893,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6744669-6749865,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6744669-6752725,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6744669-6756733,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6744669-6790607,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6744669-6833758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6744669-6848618,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6744669-6975321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6744669-6980948,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6744669-6981673,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6744669-6991122,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6744669-7034769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6744669-7054358,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6744669-7299137,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6744669-7366733
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
57
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
195-206
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6744669-Adult,
pubmed-meshheading:6744669-Aged,
pubmed-meshheading:6744669-Antibodies, Monoclonal,
pubmed-meshheading:6744669-Child,
pubmed-meshheading:6744669-Female,
pubmed-meshheading:6744669-Fetus,
pubmed-meshheading:6744669-Humans,
pubmed-meshheading:6744669-Killer Cells, Natural,
pubmed-meshheading:6744669-Lymphoid Tissue,
pubmed-meshheading:6744669-Lymphoproliferative Disorders,
pubmed-meshheading:6744669-Male,
pubmed-meshheading:6744669-Middle Aged,
pubmed-meshheading:6744669-Neoplasms
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pubmed:year |
1984
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pubmed:articleTitle |
Distribution and heterogeneity of cells detected by HNK-1 monoclonal antibody in blood and tissues in normal, reactive and neoplastic conditions.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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