Linked Life Data

6712707

Source:http://linkedlifedata.com/resource/pubmed/id/6712707

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1984-5-10
pubmed:abstractText
Human bronchus, in short-term explant culture, metabolized 1-naphthol to both its sulphate ester and glucuronic acid conjugates. At low concentrations of 1-naphthol (20 microM), more 1-naphthyl sulphate than 1-naphthyl-beta-D-glucuronide was formed. At similar substrate concentrations, short-term explant cultures of both bronchus without cartilage and bronchoscopy samples, which consisted largely of bronchial epithelium, formed predominantly 1-naphthyl-beta-D-glucuronide. Thus cartilage, which alone did not significantly metabolize 1-naphthol, may in some way influence the metabolism of 1-naphthol by intact bronchus. A large inter-individual variation was observed in the conjugation of 1-naphthol by cultured human bronchus. Such variations in the conjugation of chemicals may be of importance in determining individual susceptibility to chemically induced damage.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0006-2952
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
33
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
739-43
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Conjugation of 1-naphthol by human bronchus and bronchoscopy samples.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't