Linked Life Data

6451777

Source:http://linkedlifedata.com/resource/pubmed/id/6451777

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1981-5-13
pubmed:abstractText
Female BALB/c mice at 5, 6 (immature) and 35 weeks of age (mature) were placed on isocaloric control (20% protein) or experimental (4% protein) diets. Cell-mediated immune responses [theta-bearing cell percentages, phytohemagglutinin (PHA) induced mitogenesis, mixed lymphocyte reaction (MLR) and antibody-dependent lymphocyte-mediated cytotoxicity (ADLMC)] of splenic lymphocytes were measured. A significant decline in percentages of theta-bearing cells, PHA and MLR responses occurred as early as two weeks for the immature mice on the restricted diet and continued for up to 8 weeks. In mature mice, protein restriction did not influence theta-bearing cell percentages, but did suppress PHA and MLR responses between 7 and 13 weeks. A significant suppression of ADLMC responses were also noted at 16 weeks. These results indicate that developing cellular immune systems of immature BALB/c mice are more sensitive to moderate protein restriction (i.e. immunosuppression occurs after a shorter interval) than those of mature mice. They suggest that moderate protein malnutrition retards but does not prevent immunological maturation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0047-6374
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
269-78
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Modifications of cell-mediated immune responses by moderate dietary protein stress in immunologically immature and mature BALB/c mice.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't