|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
11
|
|
pubmed:dateCreated |
1984-7-25
|
|
pubmed:abstractText |
The bacteriophage P1 genome carries an invertible C segment consisting of 3-kb unique sequences flanked by 0.6-kb inverted repeats. With insertion and deletion mutants of P1 derivatives the site-specific recombinase gene cin for C inversion) has been mapped adjacent to the C segment and the cix sites (for C inversion cross-over) have been located at the outside ends of the inverted repeats. Inversion of the C segment functions as a biological switch and controls expression of the gene(s) responsible for phage infectivity carried on the C segment. The cin gene product can promote recombination between a 'quasi- cix ' site on plasmid pBR322 and a cix site on P1 DNA. The junctions formed on the resulting co-integrate can also serve as cix sites. This observation implies a potential evolutionary process to bring genes under the control of a biological switch acting by DNA inversion.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6327269-1108412,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6327269-158470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6327269-231182,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6327269-273224,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6327269-289897,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6327269-322277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6327269-344137,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6327269-372970,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6327269-375194,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6327269-381673,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6327269-385224,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6327269-419685,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6327269-4567745,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6327269-4598005,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6327269-4615160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6327269-4712391,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6327269-584611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6327269-6100897,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6327269-6102553,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6327269-6116279,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6327269-6210848,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6327269-6244582,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6327269-6245339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6327269-6247612,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6327269-6248430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6327269-6250048,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6327269-6259828,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6327269-6269755,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6327269-6269756,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6327269-6270656,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6327269-6271451,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6327269-6271452,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6327269-6271453,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6327269-6271461,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6327269-6271475,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6327269-6278242,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6327269-6294706,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6327269-6457723,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6327269-6461289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6327269-685175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6327269-7038403,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6327269-895711,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6327269-895712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6327269-982820
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0261-4189
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
1
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1445-53
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:6327269-Base Sequence,
pubmed-meshheading:6327269-Chromosome Deletion,
pubmed-meshheading:6327269-Coliphages,
pubmed-meshheading:6327269-Crossing Over, Genetic,
pubmed-meshheading:6327269-DNA, Recombinant,
pubmed-meshheading:6327269-DNA Nucleotidyltransferases,
pubmed-meshheading:6327269-DNA Restriction Enzymes,
pubmed-meshheading:6327269-DNA Transposable Elements,
pubmed-meshheading:6327269-Escherichia coli,
pubmed-meshheading:6327269-Genes,
pubmed-meshheading:6327269-Genes, Viral,
pubmed-meshheading:6327269-Plasmids
|
|
pubmed:year |
1982
|
|
pubmed:articleTitle |
A site-specific, conservative recombination system carried by bacteriophage P1. Mapping the recombinase gene cin and the cross-over sites cix for the inversion of the C segment.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
