| pubmed-article:6245244 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6245244 | lifeskim:mentions | umls-concept:C0016720 | lld:lifeskim |
| pubmed-article:6245244 | lifeskim:mentions | umls-concept:C0042776 | lld:lifeskim |
| pubmed-article:6245244 | lifeskim:mentions | umls-concept:C0012939 | lld:lifeskim |
| pubmed-article:6245244 | lifeskim:mentions | umls-concept:C0040669 | lld:lifeskim |
| pubmed-article:6245244 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:6245244 | lifeskim:mentions | umls-concept:C1522642 | lld:lifeskim |
| pubmed-article:6245244 | lifeskim:mentions | umls-concept:C0205250 | lld:lifeskim |
| pubmed-article:6245244 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:6245244 | pubmed:dateCreated | 1980-6-25 | lld:pubmed |
| pubmed-article:6245244 | pubmed:abstractText | Unintegrated viral DNA was isolated via the Hirt procedure from mouse fibroblasts newly infected with Friend murine leukemia virus (F-MuLV) clone 201, a biologically cloned helper virus isolated from stocks of F-MuLV complex. A physical map of the unintegrated in vivo linear viral DNA was generated for several restriction endonucleases. The supercoiled viral DNA was digested with EcoRI, which cleaved the viral DNA at a unique site. The linearized viral DNA was then inserted into lambda gtWES.lambda B at the EcoRI site and cloned in an approved EK2 host. Eight independent lambda-mouse recombinants were identified as containing F-MuLV DNA inserts by hybridization with F-MuLV 32P-labeled complementary DNA. One of the F-MuLV DNA inserts was 9.1 kilobases (kb) and had the same restriction enzyme sites as the unintegrated linear F-MuLV DNA. Six inserts were 8.5 kb; each lacked a single copy of the terminally redundant sequences of the unintegrated linear viral DNA. One insert was 8.2 kb and contained a 0.9-kb deletion. After digestion with EcoRI, one recombinant DNA preparation containing an 8.5-kb insert was infectious for NIH 3T3 cells. Undigested recombinant DNA was not infectious. The infectivity of the EcoRI-digested DNA followed multihit kinetics, indicating that more than one molecule was required to register as an infectious unit. The virus isolated from this transfection (F-MuLV-57) was NB-ecotropic, helper-independent, and formed XC plaques. Inoculation of this virus into newborn NIH Swiss mice induced leukemia and splenomegaly in greater than 90% of animals within 3 to 4 weeks. The gross and microscopic abnormalities induced by F-MuLV clone 57 were identical to those seen with the original parent stocks of F-MuLV clone 201. These results indicate that this helper-independent F-MuLV can induce a rapid nonthymic leukemia in the absence of the spleen focus-forming virus. | lld:pubmed |
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| pubmed-article:6245244 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6245244 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6245244 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6245244 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6245244 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:6245244 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:6245244 | pubmed:author | pubmed-author:ScolnickE MEM | lld:pubmed |
| pubmed-article:6245244 | pubmed:author | pubmed-author:LowyD RDR | lld:pubmed |
| pubmed-article:6245244 | pubmed:author | pubmed-author:HagerG LGL | lld:pubmed |
| pubmed-article:6245244 | pubmed:author | pubmed-author:ChangE HEH | lld:pubmed |
| pubmed-article:6245244 | pubmed:author | pubmed-author:OliffA IAI | lld:pubmed |
| pubmed-article:6245244 | pubmed:author | pubmed-author:ChanH WHW | lld:pubmed |
| pubmed-article:6245244 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6245244 | pubmed:volume | 33 | lld:pubmed |
| pubmed-article:6245244 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6245244 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6245244 | pubmed:pagination | 475-86 | lld:pubmed |
| pubmed-article:6245244 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:6245244 | pubmed:year | 1980 | lld:pubmed |
| pubmed-article:6245244 | pubmed:articleTitle | Transfection of molecularly cloned Friend murine leukemia virus DNA yields a highly leukemogenic helper-independent type C virus. | lld:pubmed |
| pubmed-article:6245244 | pubmed:publicationType | Journal Article | lld:pubmed |
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