|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4677
|
|
pubmed:dateCreated |
1984-12-26
|
|
pubmed:abstractText |
Platelet-derived growth factor (PDGF) has been previously shown to be homologous to the transforming gene of simian sarcoma virus (v-sis), and inappropriate expression of the cellular counterpart of the v-sis gene (c-sis) has been implicated in the generation of mesenchymal tumors. The U-2 OS human osteosarcoma line was shown to contain multiple c-sis transcripts. Immunoprecipitation experiments with antiserum to PDGF identified a variety of polypeptides ranging in size from 18,000 to 165,000 daltons that were immunoprecipitated specifically from U-2 OS cell extracts. The osteosarcoma also was shown to secrete a 29,000-dalton protein having the serological and structural characteristics of PDGF.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0036-8075
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
23
|
|
pubmed:volume |
226
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
972-4
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:6209798-Cell Line,
pubmed-meshheading:6209798-DNA Replication,
pubmed-meshheading:6209798-Humans,
pubmed-meshheading:6209798-Molecular Weight,
pubmed-meshheading:6209798-Neoplasm Proteins,
pubmed-meshheading:6209798-Oncogenes,
pubmed-meshheading:6209798-Osteosarcoma,
pubmed-meshheading:6209798-Platelet-Derived Growth Factor,
pubmed-meshheading:6209798-Poly A,
pubmed-meshheading:6209798-RNA,
pubmed-meshheading:6209798-RNA, Messenger,
pubmed-meshheading:6209798-Transcription, Genetic
|
|
pubmed:year |
1984
|
|
pubmed:articleTitle |
Detection of c-sis transcripts and synthesis of PDGF-like proteins by human osteosarcoma cells.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
