Linked Life Data

6112044

Source:http://linkedlifedata.com/resource/pubmed/id/6112044

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1981-7-23
pubmed:abstractText
Submaximal destruction of nigrostriatal dopaminergic projections resulted in a significant (25%) decrease in specific GABA binding in substantia nigra; under these conditions, striatal tyrosine hydroxylase activity was 15-44% of control. In rats with lesions which caused maximal destruction of nigrostriatal dopamine neurons (striatal tyrosine hydroxylase was less than 15% of control), specific GABA binding in substantia nigra was apparently not different from that obtained in intact controls. Two distinct processes may be occurring in response to the destruction of dopamine neurons: (1) the loss of GABA binding sites physically associated with nigral dopamine neurons; and (2) an increase in nigral GABA receptors associated with non-dopaminergic neurons. The latter process may result from a decrease in nigral GABA transmission secondary to the complete loss of dopaminergic synaptic activity in striatum.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
6
pubmed:volume
210
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
401-6
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Relationship between the presence of dopaminergic neurons and GABA receptors in substantia nigra: effects of lesions.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't