GABA Receptor

Source:http://linkedlifedata.com/resource/umls/id/C0206518

MSH: Cell-surface proteins that bind GAMMA-AMINOBUTYRIC ACID with high affinity and trigger changes that influence the behavior of cells. GABA-A receptors control chloride channels formed by the receptor complex itself. They are blocked by bicuculline and usually have modulatory sites sensitive to benzodiazepines and barbiturates. GABA-B receptors act through G-proteins on several effector systems, are insensitive to bicuculline, and have a high affinity for L-baclofen.,CSP: regulate a family of transmembrane chloride channels such that binding of GABA or its analogs permits increased chloride influx, membrane hyperpolarization, and inhibition of postsynaptic electrical activity.

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