Linked Life Data

542952

Source:http://linkedlifedata.com/resource/pubmed/id/542952

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1980-6-25
pubmed:abstractText
The role of metallothionein (MT) in the mechanism of cadmium absorption from the jejunum was studied in 7--9 week-old-male rats exposed to 50 ppm of cadmium in drinking water for 9 days. Exposed animals contained an average of 144 micrograms MT/g of mucosal tissue, compared to 40 micrograms in control anaimls. During jejunal perfusion in situ with 5 mM glucose-saline containing 10--20 nM CdCl2 the increased MT content of mucosa exerted no effect either on cadmium absorption from the lumen (step I), or on its further transport into the body (step II). Immediately after perfusion, essentially all cadmium removed from the lumen was fully recovered in the intestinal mucosa. About 50% of the mucosal cadmium was found in the sediment after homogenization and centrifugation; a large portion of this cadmium may be assigned to the membrane fraction. The binding of freshly absorbed cadmium in the mucosal cytosol was not restricted to low molecular weight protein, although cadmium binding capacity in the MT fraction of controls as well as of exposed animals greatly exceeded actual binding of newly absorbed cadmium. Our results offer no support for the view that MT in the jejunal mucosa serves as determinant of cadmium absorption.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0300-483X
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
199-208
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1979
pubmed:articleTitle
On the role of metallothionein in cadmium absorption by rat jejunum in situ.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.