Linked Life Data

4723797

Source:http://linkedlifedata.com/resource/pubmed/id/4723797

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1973-10-11
pubmed:abstractText
1. Experiments were done on isolated tissues from mice injected with 0.9% w/v NaCl solution (saline), 6-hydroxydopamine (6-OHDA), nerve-growth-factor antiserum (NGF-As) or a combination of these agents (NGF-As+6-OHDA).2. Fluorescence histochemistry of vasa deferentia showed clear differences between each of the treatments but no such distinction was possible in cardiac ventricle or intestine.3. Compared with controls, the chronotropic responses of atria to field stimulation were reduced by all three treatments in the order NGF-As<6-OHDA<NGF-As+6-OHDA. Supersensitivity to noradrenaline occurred in atria from all treated groups.4. In contrast, vasa deferentia from NGF-As-treated mice responded almost identically with controls to both field stimulation and to exogenous noradrenaline. Considerable functional impairment and noradrenaline supersensitivity were obvious in both the 6-OHDA and the NGF-As+6-OHDA groups but no distinction could be made between them.5. The relaxation of superfused ileum following nerve stimulation was reduced in the NGF-As group, whilst preparations from the two groups given 6-OHDA usually gave a motor response which was blocked by atropine.6. None of the treatments employed in these experiments caused complete sympathectomy although 6-OHDA alone or in combination with NGF-As produced a more pronounced effect than NGF-As alone and the relative ineffectiveness of the latter is discussed. The implications of the motor response after 6-OHDA in ileum when the nerves were stimulated is considered in the light of the cholinergic link hypothesis.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/4723797-13320365, http://linkedlifedata.com/resource/pubmed/commentcorrection/4723797-13806189, http://linkedlifedata.com/resource/pubmed/commentcorrection/4723797-14290806, http://linkedlifedata.com/resource/pubmed/commentcorrection/4723797-16578497, http://linkedlifedata.com/resource/pubmed/commentcorrection/4723797-4316531, http://linkedlifedata.com/resource/pubmed/commentcorrection/4723797-4337865, http://linkedlifedata.com/resource/pubmed/commentcorrection/4723797-4392577, http://linkedlifedata.com/resource/pubmed/commentcorrection/4723797-4397440, http://linkedlifedata.com/resource/pubmed/commentcorrection/4723797-4863647, http://linkedlifedata.com/resource/pubmed/commentcorrection/4723797-4930688, http://linkedlifedata.com/resource/pubmed/commentcorrection/4723797-5328856, http://linkedlifedata.com/resource/pubmed/commentcorrection/4723797-5879781
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0007-1188
pubmed:author
pubmed:issnType
Print
pubmed:volume
47
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
748-59
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1973
pubmed:articleTitle
An assessment of sympathetic function in isolated tissues from mice given nerve-growth-factor antiserum and 6-hydroxydopamine.
pubmed:publicationType
Journal Article, In Vitro