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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1985-2-8
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pubmed:abstractText |
We have tested the interaction between serotonin and secretin in pentagastrin-induced gastric acid secretion in six dogs prepared with Thomas gastric and duodenal cannulas. We further examined the effect of methysergide, a serotonin antagonist, on gastric acid secretion. The intravenous administration of serotonin or secretin alone significantly inhibited pentagastrin-induced gastric acid secretion. The combined administration of serotonin and secretin inhibited gastric acid secretion to a greater magnitude than either secretagogue alone. The administration of methysergide diminished basal concentrations of secretin on gastric acid secretion. Methysergide also enhanced the stimulatory activity of pentagastrin-induced gastric acid secretion. The inhibitory action of intraduodenal acidification of pentagastrin-induced gastric acid secretion was reversed by methysergide.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0002-9610
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
149
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
40-5
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:3966640-Animals,
pubmed-meshheading:3966640-Dogs,
pubmed-meshheading:3966640-Drug Synergism,
pubmed-meshheading:3966640-Duodenum,
pubmed-meshheading:3966640-Gastric Acid,
pubmed-meshheading:3966640-Gastrins,
pubmed-meshheading:3966640-Humans,
pubmed-meshheading:3966640-Hydrochloric Acid,
pubmed-meshheading:3966640-Infusions, Parenteral,
pubmed-meshheading:3966640-Male,
pubmed-meshheading:3966640-Methysergide,
pubmed-meshheading:3966640-Pentagastrin,
pubmed-meshheading:3966640-Secretin,
pubmed-meshheading:3966640-Serotonin,
pubmed-meshheading:3966640-Time Factors
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pubmed:year |
1985
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pubmed:articleTitle |
Regulation of gastric acid secretion by secretin and serotonin.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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