3947361

Source:http://linkedlifedata.com/resource/pubmed/id/3947361

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0018873, umls-concept:C0035820, umls-concept:C0120465, umls-concept:C0597295, umls-concept:C0871161, umls-concept:C1704686, umls-concept:C1998793
pubmed:issue	3
pubmed:dateCreated	1986-3-21
pubmed:abstractText	A guanine nucleotide exchange factor (GEF), catalyzing the exchange of GDP bound to initiation factor eIF-2 for GTP, has been isolated from S3 HeLa cells as the eIF-2 X GEF complex and extensively purified by procedures originally developed for purification of GEF from rabbit reticulocytes. The HeLa cell factor resembles rabbit reticulocyte eIF-2 X GEF in polypeptide composition, catalytic activity, and inactivation by alpha-phosphorylated eIF-2.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0372516
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Eukaryotic Initiation Factor-2, http://linkedlifedata.com/resource/pubmed/chemical/Guanine Nucleotide Exchange Factors, http://linkedlifedata.com/resource/pubmed/chemical/Guanosine Diphosphate, http://linkedlifedata.com/resource/pubmed/chemical/Guanosine Triphosphate, http://linkedlifedata.com/resource/pubmed/chemical/Peptide Initiation Factors, http://linkedlifedata.com/resource/pubmed/chemical/Proteins
pubmed:status	MEDLINE
pubmed:month	Feb
pubmed:issn	0006-291X
pubmed:author	pubmed-author:MarianoT MTM, pubmed-author:OchoaSS, pubmed-author:SiekierkaJJ
pubmed:issnType	Print
pubmed:day	13
pubmed:volume	134
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	1160-6
pubmed:dateRevised	2008-11-21
pubmed:meshHeading	pubmed-meshheading:3947361-Animals, pubmed-meshheading:3947361-Catalysis, pubmed-meshheading:3947361-Chemistry, Physical, pubmed-meshheading:3947361-Electrophoresis, Polyacrylamide Gel, pubmed-meshheading:3947361-Eukaryotic Initiation Factor-2, pubmed-meshheading:3947361-Guanine Nucleotide Exchange Factors, pubmed-meshheading:3947361-Guanosine Diphosphate, pubmed-meshheading:3947361-Guanosine Triphosphate, pubmed-meshheading:3947361-HeLa Cells, pubmed-meshheading:3947361-Humans, pubmed-meshheading:3947361-Peptide Chain Initiation, Translational, pubmed-meshheading:3947361-Peptide Initiation Factors, pubmed-meshheading:3947361-Physicochemical Phenomena, pubmed-meshheading:3947361-Protein Biosynthesis, pubmed-meshheading:3947361-Proteins, pubmed-meshheading:3947361-Rabbits, pubmed-meshheading:3947361-Reticulocytes
pubmed:year	1986
pubmed:articleTitle	Purification and properties of the guanine nucleotide exchange factor (GEF) from HeLa cells and its role in the initiation of protein synthesis.
pubmed:publicationType	Journal Article