Linked Life Data

3933911

Source:http://linkedlifedata.com/resource/pubmed/id/3933911

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1986-1-8
pubmed:abstractText
To assess the adequacy of tissue oxygenation in fulminant hepatic failure, we measured arterial oxygen delivery, the affinity of hemoglobin for oxygen, mixed venous oxygen tension, and lactate concentration in 32 patients suffering grade IV encephalopathy. In the patients who died, median systemic vascular resistance and oxygen extraction ratio were significantly (p less than .005) lower than in those who survived (1268 vs. 1866 dyne . sec/cm5 . m2 and 20% vs. 25%, respectively) despite a significantly (p less than .01) greater oxygen delivery in the former group (716 vs. 570 ml/min . m2). Furthermore, nonsurvivors had significantly greater in vivo P50 and mixed venous lactate values (31 vs. 29.5 torr [p less than .02], and 5.1 vs 3.0 mmol/L [p less than .05], respectively). Only in survivors was the in vivo P50 related to the oxygen extraction ratio (r = 0.68 and p less than .01, compared with r = 0.03 in nonsurvivors). These results suggest that the fall in systemic vascular resistance is related to some form of arteriovenous shunting and that this is more severe in patients who die. The subsequent development of tissue hypoxia is an important prognostic factor in fulminant hepatic failure that may contribute to the occurrence of irreversible multiple organ failure.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0090-3493
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1034-9
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Tissue hypoxia during fulminant hepatic failure.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't