| pubmed-article:3866117 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3866117 | lifeskim:mentions | umls-concept:C0023467 | lld:lifeskim |
| pubmed-article:3866117 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
| pubmed-article:3866117 | lifeskim:mentions | umls-concept:C0022265 | lld:lifeskim |
| pubmed-article:3866117 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:3866117 | lifeskim:mentions | umls-concept:C1511938 | lld:lifeskim |
| pubmed-article:3866117 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
| pubmed-article:3866117 | lifeskim:mentions | umls-concept:C0733521 | lld:lifeskim |
| pubmed-article:3866117 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:3866117 | pubmed:dateCreated | 1986-1-29 | lld:pubmed |
| pubmed-article:3866117 | pubmed:abstractText | An alternative to a cell-kill strategy for eradication of acute myelogenous leukemia, is to restore normal differentiation. Vitamin A derivatives demonstrate differentiation-inducing activity both in vitro and in vivo on promyelocytic leukemic cells. We tested the ability of 13-cis retinoic acid to reduce proliferation and induce differentiation in 10 samples from patients with acute non-promyelocytic leukemia. DNA synthesis and leukemia colony formation were affected to varying degrees by a prolonged exposure to the vitamin A compound. Morphologically and cytochemically no differentiation was determined either after 48 h in suspension cultures or 7 additional days in semi-solid cultures. Alkaline leukocyte phosphatase, a biochemical marker of differentiation, was significantly increased in five samples. DNA synthesis in these samples was significantly reduced as compared to samples failing to express alkaline leukocyte phosphatase following 13-cis retinoic acid treatment. DNA synthesis of these same 5 samples was also strongly inhibited by Ara-C. Expression of alkaline leukocyte phosphatase following 13-cis retinoic acid exposure may be a useful indicator for cells amenable to 13-cis retinoic acid or Ara-C treatment. | lld:pubmed |
| pubmed-article:3866117 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3866117 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3866117 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3866117 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3866117 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3866117 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3866117 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3866117 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3866117 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3866117 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3866117 | pubmed:issn | 0145-2126 | lld:pubmed |
| pubmed-article:3866117 | pubmed:author | pubmed-author:HofmannVV | lld:pubmed |
| pubmed-article:3866117 | pubmed:author | pubmed-author:KistlerGG | lld:pubmed |
| pubmed-article:3866117 | pubmed:author | pubmed-author:MoreillonM... | lld:pubmed |
| pubmed-article:3866117 | pubmed:author | pubmed-author:MerchantR ERE | lld:pubmed |
| pubmed-article:3866117 | pubmed:author | pubmed-author:CogoliMM | lld:pubmed |
| pubmed-article:3866117 | pubmed:author | pubmed-author:BerensM EME | lld:pubmed |
| pubmed-article:3866117 | pubmed:author | pubmed-author:FrühUU | lld:pubmed |
| pubmed-article:3866117 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3866117 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:3866117 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3866117 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3866117 | pubmed:pagination | 1367-71 | lld:pubmed |
| pubmed-article:3866117 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:3866117 | pubmed:meshHeading | pubmed-meshheading:3866117-... | lld:pubmed |
| pubmed-article:3866117 | pubmed:meshHeading | pubmed-meshheading:3866117-... | lld:pubmed |
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| pubmed-article:3866117 | pubmed:meshHeading | pubmed-meshheading:3866117-... | lld:pubmed |
| pubmed-article:3866117 | pubmed:meshHeading | pubmed-meshheading:3866117-... | lld:pubmed |
| pubmed-article:3866117 | pubmed:meshHeading | pubmed-meshheading:3866117-... | lld:pubmed |
| pubmed-article:3866117 | pubmed:meshHeading | pubmed-meshheading:3866117-... | lld:pubmed |
| pubmed-article:3866117 | pubmed:meshHeading | pubmed-meshheading:3866117-... | lld:pubmed |
| pubmed-article:3866117 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:3866117 | pubmed:articleTitle | Effects of 13-cis retinoic acid and Ara-C on differentiation and proliferation of non-promyelocytic acute myelogenous leukemia. | lld:pubmed |
| pubmed-article:3866117 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3866117 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
