Isotretinoin

Source:http://linkedlifedata.com/resource/umls/id/C0022265

MSH: A topical dermatologic agent that is used in the treatment of ACNE VULGARIS and several other skin diseases. The drug has teratogenic and other adverse effects.,CSP: a topical dermatologic agent that is used in the treatment of acne vulgaris and several other skin diseases.,NCI: A drug that is used in the treatment of acne and psoriasis and is being studied in cancer prevention. It is a type of retinoid.,NCI: A naturally-occurring retinoic acid with potential antineoplastic activity. Isotretinoin binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promote cell differentiation and apoptosis. This agent also exhibits immunomodulatory and anti-inflammatory responses and inhibits ornithine decarboxylase, thereby decreasing polyamine synthesis and keratinization.,PDQ: A naturally-occurring retinoic acid with potential antineoplastic activity and teratogenic properties. 13-cis retinoic acid binds to and activates nuclear retinoic acid receptors (RAR

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