Linked Life Data

3609540

Source:http://linkedlifedata.com/resource/pubmed/id/3609540

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1987-8-28
pubmed:abstractText
Male Sprague-Dawley rats (three per treatment group) were administered 0, 2, 10, 20, or 40 mg aluminum per kilogram ip per day for 3 days as aluminum chloride in saline. Animals were killed 24 hr later. Aluminum was found to inhibit hepatic drug metabolism in a dose-dependent fashion. The lowest dose (2 mg or 75 mumol/kg) had no effect on the parameters measured, whereas the highest dose (40 mg or 1.5 mmol/kg) caused a 52% decrease in cytochrome P-450, a 71% decrease in p-nitrophenetole O-deethylase activity, and a 77% decrease in ethylmorphine N-demethylase activity. Hepatic glutathione levels were unaffected by aluminum, whereas metallothionein (MT) was induced in both liver and kidney. The distribution of endogenous metals normally associated with MT was altered by aluminum administration. At the highest dose of aluminum (40 mg/kg), zinc levels were increased in liver cytosol (154%), while copper levels were unchanged in liver, but decreased in kidney (70%). Aluminum was present in the liver and kidney. Of the aluminum in the liver, less than 5% was in the cytosol, bound to a MT-like protein. It is concluded that acute ip administration of aluminum adversely effects hepatic drug metabolism and that aluminum induces and binds to MT or a MT-like protein.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0272-0590
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
541-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
In vivo interactions of aluminum with hepatic cytochrome P-450 and metallothionein.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.